Topical recombinant human thrombin in surgical hemostasis

Seminars in Thrombosis and Hemostasis
Lyndsey J BowmanWilliam C Chapman

Abstract

The achievement of hemostasis is paramount, and good operative practice is crucial to all surgical procedures. Intraoperative hemostasis is usually achieved through suture ligation for larger vessels and electrocautery of smaller vessels; certain cases, however, are not amenable to these techniques, especially when there is diffuse raw surface bleeding. When operative hemorrhage exists despite appropriate preventive actions and good surgical technique, additional methods for controlling intra- and perioperative hemorrhage should be considered, and may include the use of topical thrombin. Recombinant human thrombin (rhThrombin) was approved by the Food and Drug Administration in 2008, with the expectation of overcoming the disadvantages of previously available topical thrombin preparations. The efficacy of rhThrombin has been demonstrated in three randomized controlled trials and found to be effective for achieving hemostasis within 10 minutes of administration for mild to moderate diffuse raw surface bleeding. rhThrombin is equally as effective as bovine thrombin, with a significantly lower risk of immunogenicity. Similar economic parameters, efficacy, and safety profiles between rhThrombin and other available thrombin preparat...Continue Reading

Citations

Nov 6, 2010·Journal of Thrombosis and Thrombolysis·Massimo Franchini, Giuseppe Lippi
Jan 20, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Giuseppe LippiMassimo Franchini
Feb 7, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Henry H I YaoKatharine J Drummond
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Apr 15, 2020·Expert Review of Hematology·Massimo FranchiniGiancarlo Maria Liumbruno
Dec 7, 2019·Hematology·Marzia MenegattiFlora Peyvandi

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