Abstract
Open fractures become infected despite meticulous debridement and care. Locally applied antibiotics, commonly embedded in polymethylmethacrylate, deliver high doses of drug directly to the fracture site. Direct application of antibiotic powder, which is being applied prophylactically in spine surgery, is a recent interest in the trauma sector, where bacterial biofilms are more prevalent. Traditional antibiotics, such as vancomycin, are poor performers against bacterial biofilms thus are ineffective in delayed treatment. Rifampin is an effective eradicator of Staphylococcal biofilms. Here, a rat model of musculoskeletal trauma was used to evaluate the utility of locally applied rifampin powder for reducing established orthopedic Staphylococcal infections in a delayed treatment scenario that previously indicated the limited use of local vancomycin. By applying rifampin powder directly to the contaminated segmental defect, the number of bacteria, as well as clinical indications of infection, were significantly reduced compared to vancomycin and daptomycin. Considering the Infectious Disease Society of America's recommendation to use rifampin in combination with another antibiotic to reduce the onset of rifampin resistance, rifampi...Continue Reading
References
Apr 1, 1989·American Journal of Surgery·J H Calhoun, J T Mader
May 30, 1998·JAMA : the Journal of the American Medical Association·W ZimmerliP E Ochsner
Jun 12, 2001·Methods in Enzymology·H CeriB Olson
Aug 2, 2005·Clinical Orthopaedics and Related Research·J William Costerton
May 20, 2008·Acta Orthopaedica·Konstantinos AnagnostakosJens Kelm
Nov 8, 2008·Archives of Orthopaedic and Trauma Surgery·Dennis A K Rice, Luke Mendez-Vigo
Feb 10, 2011·Spine·Fred A SweetChristopher Sliva
Sep 20, 2011·The Journal of Trauma·Duane R HospenthalUNKNOWN Surgical Infection Society
Jan 6, 2012·The Journal of Bone and Joint Surgery. British Volume·J G Penn-BarwellJ C Wenke
Oct 11, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P Sendi, W Zimmerli
Nov 15, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·W Zimmerli
Aug 7, 2013·Antimicrobial Agents and Chemotherapy·Jared A NiskaLloyd S Miller
Jun 13, 2014·Journal of Clinical Microbiology·Christopher D Doern
Jul 6, 2014·Diagnostic Microbiology and Infectious Disease·Jaime Lora-TamayoAlex Soriano
Jul 19, 2014·BMC Research Notes·Anthony P CardileKevin S Akers
Aug 22, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Stephen J McConougheyJason H Calhoun
Feb 1, 2015·The Spine Journal : Official Journal of the North American Spine Society·Daniel G KangRonald A Lehman
Apr 22, 2015·Clinical Orthopaedics and Related Research·Carlos J SanchezJoseph C Wenke
May 11, 2015·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Keerat SinghHassan R Mir
May 15, 2015·Foot & Ankle International·Dane K WukichBedda L Rosario
May 27, 2015·Injury·Mark E HakeCyril Mauffrey
Nov 5, 2015·European Cells & Materials·J A InzanaH A Awad
Apr 29, 2016·Journal of Orthopaedic Trauma·David J TennentJoseph C Wenke
May 14, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Virginia PostT Fintan Moriarty
Jun 28, 2016·BMC Infectious Diseases·Elizabeth D HermsenKenneth C Lamp
Sep 19, 2016·Injury·W J MetsemakersM Morgenstern
Mar 23, 2017·Journal of Orthopaedic Trauma·Robert V OʼTooleUNKNOWN METRC
Mar 25, 2017·The Orthopedic Clinics of North America·David C CarverJohn C Weinlein
Aug 27, 2017·Injury·Stefanie M ShielsJoseph C Wenke
Citations
Oct 3, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stefanie M ShielsJoseph C Wenke
May 1, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yang XieWen Xie
Jul 23, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michiel CroesH Charles Vogely
Nov 14, 2019·Pharmaceutics·Raquib HasanAmanda Brooks
Aug 30, 2019·Journal of Orthopaedic Trauma·Willem-Jan MetsemakersUNKNOWN Fracture-Related Infection (FRI) consensus group
Jan 5, 2021·The Journal of Bone and Joint Surgery. American Volume·UNKNOWN Machine Learning Consortium, on behalf of the SPRINT and FLOW Investigators
Jun 10, 2020·Journal of Orthopaedic Trauma·Kristen BraoJanette M Harro
Oct 31, 2020·BioMed Research International·Jan Miroslav HartingerTomáš Grus