Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study

Journal of Cosmetic Dermatology
Ahmad NofalShimaa Osman

Abstract

Melasma is a highly prevalent hyperpigmentation disorder with a high relapsing rate and a negative impact on the psychological state of the affected patients. The exact pathogenesis of melasma is not completely elucidated; however, ultraviolet induced oxidative stress has an important role in its pathogenesis. Silymarin, antioxidant drug, reduces the harmful effects of solar ultraviolet radiation such as inflammation, immune responses, DNA damage, and pigmentation. To assess the efficacy and safety of topical silymarin with different concentrations (0.7% and 1.4%) versus hydroquinone 4% in the treatment of melasma. Forty-two adult female patients with melasma were assigned to three equal groups each containing 14 patients; group1 was treated by silymarin 0.7% cream, group 2 was treated by silymarin 1.4% cream and group 3 was treated by hydroquinone 4% cream. The duration of treatment was 3 months. MASI score was significantly reduced in all groups at the end of third month; however, there were no significant differences in the therapeutic response between the three studied groups. No side effects were recorded with silymarin, while hydroquinone was associated with significant adverse effects. Silymarin cream might serve as an e...Continue Reading

Associated Clinical Trials

References

Mar 11, 2004·The Journal of Investigative Dermatology·Kazuhisa Maeda, Masato Hatao
Sep 20, 2005·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Vladimír Kren, Daniela Walterová
Mar 14, 2007·Journal of Cosmetic Dermatology·Tania Ferreira CestariMaria de Lourdes Viegas
Mar 17, 2007·The Journal of Dermatological Treatment·Manjiri D PawaskarRajesh Balkrishnan
Jun 3, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·J P OrtonneW Westerhof
Apr 20, 2010·Journal of the American Academy of Dermatology·Amit G PandyaJean-Paul Ortonne
Aug 9, 2011·Dermatology Research and Practice·Josefina Navarrete-SolísBenjamin Moncada
Oct 4, 2012·BMC Dermatology·Tagreed Altaei
Feb 27, 2013·Journal of Cosmetic Dermatology·Tsz Wah Tse, Edith Hui
May 30, 2013·Indian Journal of Dermatology·Rochelle C MonteiroH Kamath Ganesh
Oct 24, 2013·Cutaneous and Ocular Toxicology·Havva Yıldız SeçkinMehmet Sahin
Sep 4, 2014·Anais Brasileiros De Dermatologia·Ana Carolina HandelHélio Amante Miot
Nov 15, 2014·Indian Dermatology Online Journal·Rashmi SarkarNarendra Gokhale
Jul 17, 2015·Journal of Cosmetic Dermatology·Mahnaz BanihashemiAsma Jabari

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Citations

Aug 3, 2020·Journal of Cosmetic Dermatology·Amany Abd Elrahman NassarAsmaa Atef Mahmoud
Aug 21, 2020·International Journal of Dermatology·Kayla M BabbushAmor Khachemoune
Apr 15, 2021·The Journal of Dermatological Treatment·Nicoleta NeaguCaterina Dianzani
May 1, 2021·International Journal of Molecular Sciences·Ai-Young Lee
Aug 7, 2021·Redox Report : Communications in Free Radical Research·Dehai XianJianqiao Zhong
Jan 13, 2022·Journal of Cosmetic Dermatology·Naseem Ahmad Charoo
Feb 1, 2022·Journal of Liposome Research·Raziya Khatoon FarooquiRavi Shankar Pandey

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