Topical simvastatin promotes healing of Staphylococcus aureus-contaminated cutaneous wounds.

International Wound Journal
Chia-Chi WangYing-Chi Lin

Abstract

Cutaneous wounds are prompt to be contaminated by bacteria, but the clinical benefits of applying antibiotics and antiseptics in wound management have not been proven. Statins are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors commonly used to lower cholesterol levels. Studies indicated that statins, especially simvastatin, promote wound healing in experimental models. As Staphylococcus aureus is one of the most important microorganism responsible for wound infections, the aims of this study were to characterise the anti-staphylococcal activity of simvastatin and to evaluate the application of simvastatin as a topical therapy for S. aureus-contaminated wounds. In the present study, simvastatin was bacteriostatic against S. aureus at sub-inhibitory concentrations up to 8 hours after exposure. Further increased concentrations of simvastatin above the minimal inhibitory concentration (MIC) did not enhance the growth inhibitory effect. By contrast, the ability of simvastatin to inhibit S. aureus biofilm formation was concentration dependent. Topical application of simvastatin at its MIC against S. aureus accelerated the healing and bacterial clearance of S. aureus-contaminated wounds in an excisional mice woun...Continue Reading

References

Feb 1, 1991·The Journal of Investigative Dermatology·K R FeingoldP M Elias
Feb 3, 2000·Journal of Clinical Microbiology·A GiacomettiG Scalise
Mar 17, 2004·Current Opinion in Infectious Diseases·Ruth Edwards, Keith G Harding
May 17, 2007·Acta Cirúrgica Brasileira·Amália Cínthia Meneses do RegoAldo Cunha Medeiros
Dec 19, 2007·The Journal of Antimicrobial Chemotherapy·S Jerwood, J Cohen
Feb 12, 2008·The Journal of Antimicrobial Chemotherapy·Matthew E FalagasPetros I Rafailidis
Mar 5, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alessandra BittoFrancesco Squadrito
Mar 7, 2008·The Journal of Antimicrobial Chemotherapy·David R Nalin
Sep 5, 2008·The New England Journal of Medicine·Adam J Singer, Alexander B Dagum
Nov 4, 2008·Life Sciences·Xiang-Yang ZhuLilach O Lerman
Nov 12, 2009·The Journal of Biological Chemistry·Sasa VukelicMarjana Tomic-Canic
Jan 7, 2010·International Wound Journal·Bishara S AtiyehShady N Hayek
Mar 20, 2010·The Cochrane Database of Systematic Reviews·Marja N Storm-VerslootHester Vermeulen
Aug 28, 2010·Clinics in Dermatology·Abdul R Siddiqui, Jack M Bernstein
Nov 16, 2010·Cell Host & Microbe·Ohn A ChowVictor Nizet
Jan 13, 2011·British Journal of Clinical Pharmacology·Linda Björkhem-BergmanPeter Bergman
Sep 14, 2011·PloS One·Peter BergmanLinda Björkhem-Bergman
Nov 5, 2011·International Wound Journal·Shadi FarsaeiEffat Sadat Farboud
Mar 30, 2012·Journal of Dermatological Science·Marina AdamiMichel Fleith Otuki
May 9, 2012·Annals of Clinical Microbiology and Antimicrobials·Majed MasadehZiad Alnasser
Sep 19, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Steven L PercivalJohn W Costerton
Oct 3, 2013·Methods in Molecular Biology·James E CassatChia Y Lee
Nov 21, 2013·International Wound Journal·Georg Daeschlein
Jan 11, 2014·The Cochrane Database of Systematic Reviews·Susan O'MearaRachel Richardson
Feb 11, 2014·The British Journal of Dermatology·M T P EvangelistaL L Villafuerte
Jul 2, 2014·The Annals of Thoracic Surgery·Gerard J FitzmauriceMark E O'Donnell

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Citations

Sep 17, 2016·Scientific Reports·Suraj P PariharFrank Brombacher
Nov 1, 2017·PeerJ·Humphrey H T KoJeffery D Hughes
Jun 22, 2016·Antimicrobial Agents and Chemotherapy·Emma HennessyFergal O'Gara
May 10, 2019·Journal of Biomedical Materials Research. Part a·Christian E OlivettiGisela S Alvarez
Mar 5, 2017·Essays in Biochemistry·Katharina RichterTom Coenye
Aug 8, 2018·Infectious Disorders Drug Targets·Ritika RanaAnoop Kumar
Mar 24, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Humphrey H T KoJeffery D Hughes
Dec 12, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Andrew JullYannan Jiang

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