Topical sodium metabisulfite for the treatment of calcinosis cutis: A promising new therapy

The British Journal of Dermatology
P Del Barrio-DíazCristián Vera-Kellet

Abstract

Calcinosis cutis is a chronic calcium-mediated disease, which causes significant morbidity for patients. Multiple treatments have been tried, with varying results. Indeed, to date, no standard treatment has been generally accepted. Sodium metabisulfite is an inorganic compound that when reacts with oxygen becomes sodium sulfate, a metabolite of sodium thiosulfate, that has a similar ability to inhibit calcium oxalate agglomeration. Four female patients diagnosed with calcinosis cutis, secondary to dermatomyositis, systemic sclerosis and radiodermitis after breast cancer were evaluated for their response to topical 25% sodium metabisulfite. In all patients a decrease in size, erythema and pain from injuries was shown, with complete resolution of the associated ulcers. One patient had a complete response. No patient had adverse effects. Topical sodium metabisulfite is a new promising emerging therapy that should be considered as a valid alternative treatment in calcinosis cutis. Randomized prospective studies are required to evaluate its true efficacy. This article is protected by copyright. All rights reserved.

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Citations

Nov 22, 2017·The Journal of Dermatological Treatment·Verena Isak, Joseph L Jorizzo
Oct 28, 2017·International Journal of Dermatology·Suman PatraKaushal K Verma
Aug 21, 2018·Current Opinion in Rheumatology·Antonia ValenzuelaLorinda Chung
Nov 2, 2019·Clinical Rheumatology·C Darrieurtort-LaffiteB Le Goff
Oct 26, 2018·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Deanne M Robinson
Jun 25, 2021·Archives of Dermatological Research·Joanna NowaczykPiotr Fiedor
Jul 27, 2021·Orphanet Journal of Rare Diseases·Eric HachullaUNKNOWN Collaborators
Jul 16, 2019·Journal of the American Academy of Dermatology·Hélène TraineauFrançois Chasset
Sep 20, 2021·Journal of the American Academy of Dermatology·Jose W RicardoDeshan F Sebaratnam

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