PMID: 8593716Sep 1, 1995Paper

Topical sphingolipids in antisepsis and antifungal therapy

Clinical and Experimental Dermatology
D J BibelH R Shinefield

Abstract

Sphingosine and sphinganine, free sphingolipids of the stratum corneum, are, in vitro, strongly inhibitory for both bacteria and fungi. Whether or not they are suitable, indeed active, in vivo was examined: (i) on human volunteers, first as a preventative antiseptic against subsequently applied Staphylococcus aureus and Candida albicans, and second as a restorative antiseptic against the previously expanded normal skin flora; and (ii) on guinea-pigs as therapy for experimental C. albicans and Trichophyton mentagrophytes infections. In the antiseptic studies, which involved 200 micrograms/cm2 of sphinganine in ethanol (50 microliters of a 1.6% solution), up to three-log reductions in the population of target micro-organisms were obtained, compared with vehicle and untreated controls (P < 0.001). The daily application of sphingosine as 1.5% ethanol-petrolatum ointment was able to diminish inflammation slightly in dermatophyte-infected guinea-pigs (P = 0.02-0.05), although the animals remained culture positive over the 3-week sampling period. The candida infections, treated daily with 1.5% sphinganine in ethanol, showed no improvement in inflammation compared with controls, except for 2 days of the 2-week observation period (P = 0...Continue Reading

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Citations

Apr 13, 2013·Applied Microbiology and Biotechnology·Christoph SchorschSteffen Schaffer
Jul 20, 2002·Bioorganic & Medicinal Chemistry Letters·Gillian M NicholasTadeusz F Molinski
Jun 6, 2002·Pediatric Dermatology·Amy Gilliam, Mary L Williams
Nov 30, 2012·Eukaryotic Cell·Jessica SchneiderKarina Brinkrolf
Feb 7, 2008·Skin Pharmacology and Physiology·E HoubenV Rogiers
Nov 28, 2007·American Journal of Clinical Dermatology·Thomas HerzingerHans Christian Korting
Jun 27, 2012·Veterinary Dermatology·Ralf S MuellerRoss Bond
Apr 8, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·I Angelova-FischerD Zillikens
Sep 13, 2005·International Journal of Food Microbiology·Sam PossemiersWilly Verstraete
Jun 6, 2008·Bioorganic & Medicinal Chemistry Letters·Karin ThevissenIsabelle E J A François
Oct 2, 2007·Journal of Lipid Research·David R DrakePhilip W Wertz
Dec 17, 2017·Scientific Reports·Jérôme BecamAlexandra Schubert-Unkmeir
Sep 5, 2013·Annals of Dermatology·Sung-Hyuk MoonNack-In Kim
Mar 31, 2007·Skin Pharmacology and Physiology·E HoubenV Rogiers
Mar 1, 2006·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Bodo Melnik
Feb 15, 2020·Antibiotics·Carol L Fischer
Oct 15, 2019·Frontiers in Cell and Developmental Biology·Tobias C Kunz, Vera Kozjak-Pavlovic
Aug 11, 2004·American Journal of Clinical Dermatology·Frank RippkeHoward I Maibach
Apr 26, 2016·Veterinary Dermatology·Maarja UriVanessa M Schmidt

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