Abstract
Sphingosine and sphinganine, free sphingolipids of the stratum corneum, are, in vitro, strongly inhibitory for both bacteria and fungi. Whether or not they are suitable, indeed active, in vivo was examined: (i) on human volunteers, first as a preventative antiseptic against subsequently applied Staphylococcus aureus and Candida albicans, and second as a restorative antiseptic against the previously expanded normal skin flora; and (ii) on guinea-pigs as therapy for experimental C. albicans and Trichophyton mentagrophytes infections. In the antiseptic studies, which involved 200 micrograms/cm2 of sphinganine in ethanol (50 microliters of a 1.6% solution), up to three-log reductions in the population of target micro-organisms were obtained, compared with vehicle and untreated controls (P < 0.001). The daily application of sphingosine as 1.5% ethanol-petrolatum ointment was able to diminish inflammation slightly in dermatophyte-infected guinea-pigs (P = 0.02-0.05), although the animals remained culture positive over the 3-week sampling period. The candida infections, treated daily with 1.5% sphinganine in ethanol, showed no improvement in inflammation compared with controls, except for 2 days of the 2-week observation period (P = 0...Continue Reading
References
May 1, 1975·The Journal of Infectious Diseases·R AlyA D Mandel
Nov 1, 1992·The Journal of Investigative Dermatology·H WakitaM Takigawa
Sep 1, 1992·Canadian Journal of Microbiology·D J BibelH R Shinefield
Apr 19, 1991·Cell·H G Boman
Feb 9, 1989·Biochimica Et Biophysica Acta·A H Merrill, V L Stevens
Nov 1, 1988·The Journal of Investigative Dermatology·A K GuptaJ J Voorhees
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M Zasloff
Dec 1, 1965·The Journal of Investigative Dermatology·P Williamson, A M Kligman
Oct 1, 1982·The Journal of Investigative Dermatology·D J BibelW G Strauss
Jun 3, 1994·Journal of Chromatography. B, Biomedical Applications·N FlamandQ Gaetani
Apr 15, 1994·Science·J E Gabay
Sep 1, 1993·Clinical and Experimental Dermatology·S D Patel, W C Noble
Jan 1, 1993·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·W P ArnoldP C van de Kerkhof
Jan 1, 1993·Archives of Dermatological Research·M DendaH Tagami
Jan 4, 1993·FEBS Letters·D E Jones, C L Bevins
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K S MooreM Zasloff
Mar 1, 1981·Oecologia·Park S Nobel
Citations
Apr 13, 2013·Applied Microbiology and Biotechnology·Christoph SchorschSteffen Schaffer
Jul 20, 2002·Bioorganic & Medicinal Chemistry Letters·Gillian M NicholasTadeusz F Molinski
Jun 6, 2002·Pediatric Dermatology·Amy Gilliam, Mary L Williams
Nov 30, 2012·Eukaryotic Cell·Jessica SchneiderKarina Brinkrolf
Feb 7, 2008·Skin Pharmacology and Physiology·E HoubenV Rogiers
Apr 28, 2012·Skin Pharmacology and Physiology·N K BrogdenK A Brogden
Nov 7, 2012·Skin Pharmacology and Physiology·C L FischerP W Wertz
Aug 21, 2013·SpringerPlus·Belkassem El-AmraouiAziz Fassouane
Nov 28, 2007·American Journal of Clinical Dermatology·Thomas HerzingerHans Christian Korting
Sep 29, 2009·Veterinary Microbiology·Annemarie StrohRalf S Mueller
Aug 23, 2002·The Journal of Investigative Dermatology·Junko ArikawaGenji Imokawa
Sep 16, 2011·The Journal of Investigative Dermatology·Brenda J Curtis, Katherine A Radek
May 21, 2008·International Journal of Cosmetic Science·T PavicicH C Korting
Jun 27, 2012·Veterinary Dermatology·Ralf S MuellerRoss Bond
Apr 8, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·I Angelova-FischerD Zillikens
Sep 13, 2005·International Journal of Food Microbiology·Sam PossemiersWilly Verstraete
Mar 28, 2012·Metabolic Engineering·Daniel BörgelSteffen Schaffer
Dec 28, 1999·Genomics·S B HongE H Schuchman
Jun 6, 2008·Bioorganic & Medicinal Chemistry Letters·Karin ThevissenIsabelle E J A François
Oct 2, 2007·Journal of Lipid Research·David R DrakePhilip W Wertz
Dec 17, 2017·Scientific Reports·Jérôme BecamAlexandra Schubert-Unkmeir
Sep 5, 2013·Annals of Dermatology·Sung-Hyuk MoonNack-In Kim
Mar 31, 2007·Skin Pharmacology and Physiology·E HoubenV Rogiers
Mar 1, 2006·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Bodo Melnik
Feb 15, 2020·Antibiotics·Carol L Fischer
Oct 15, 2019·Frontiers in Cell and Developmental Biology·Tobias C Kunz, Vera Kozjak-Pavlovic
Aug 11, 2004·American Journal of Clinical Dermatology·Frank RippkeHoward I Maibach
Apr 26, 2016·Veterinary Dermatology·Maarja UriVanessa M Schmidt
Nov 7, 2019·Biochemistry. Biokhimii︠a︡·U A GutnerA V Alessenko
Nov 30, 2020·Cellular Signalling·Anke C ZieglerMarkus H Gräler