PMID: 7540269Mar 3, 1995Paper

Topical spinal administration of a nitric oxide synthase inhibitor prevents the hyper-reflexia associated with a rat model of persistent visceral pain

Neuroscience Letters
A S Rice

Abstract

The effects of a neuronal selective nitric oxide synthase (NOS) inhibitor, L-Ng-nitro arginine p-nitroanilide (L-Napna), upon the hyper-reflexia of a rat model of persistent visceral pain was investigated. A baseline cystometrogram (CMG) was performed by measuring intravesical pressure during vesical inflation. L-Napna (125-1000 micrograms) or vehicle (control) was then administered topically onto the exposed spinal cord, followed by another CMG. The bladder was then inflamed with turpentine and a final CMG performed. Neither L-Napna nor vehicle affected vesical reflexes in the absence of inflammation. However, following inflammation, a vesical hyper-reflexia was demonstrated in the control animals, which was prevented by L-Napna. Therefore, spinal NOS does not have a role in the generation of normal bladder reflexes, however it does modulate them during vesical inflammation.

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Citations

Nov 8, 2001·European Journal of Pharmacology·S V CoutinhoG F Gebhart
Nov 11, 1999·European Journal of Pharmacology·J Podhorna, R E Brown
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Dec 1, 2009·The Journal of Pain : Official Journal of the American Pain Society·Jennifer DeBerryTimothy J Ness

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