Topical tacrolimus therapy for vitiligo: therapeutic responses and skin messenger RNA expression of proinflammatory cytokines

Journal of the American Academy of Dermatology
Pearl E GrimesAllan Metzger

Abstract

Previous studies have documented humoral and cell-mediated immunologic defects in patients with vitiligo. This 24-week study assessed the efficacy and safety of tacrolimus 0.1% ointment in patients with generalized vitiligo as well as the pretreatment and post-treatment expression of cytokines in the depigmented and normal skin of patients compared with controls. Twenty-three patients were enrolled in this investigation, and 19 patients completed the study; 8 were male and 11 were female. Fifteen age-, race-, and sex-matched control subjects were also included. Patients were treated with tacrolimus 0.1% ointment applied twice daily. Repeat evaluations were performed at 4, 8, 12, 16, 20, and 24 weeks. Three-millimeter punch biopsy specimens were taken from the depigmented, non-sun-exposed skin and adjacent normal skin of patients at baseline and 24 weeks, and from normal, non-sun-exposed skin of controls. Cellular messenger RNA expression for interleukin 2 (IL-2), IL-4, IL-10, tumor necrosis factor alfa (TFN-alpha), and interferon gamma (IFN-gamma) were determined by real-time quantitative polymerase chain reaction. At 24 weeks, 17 of 19 patients (89%) achieved varying levels of repigmentation. There was a statistically signific...Continue Reading

References

Apr 1, 1992·Immunology Today·S L Schreiber, G R Crabtree
May 1, 1992·International Journal of Dermatology·M B Abdel-NaserC E Orfanos
Oct 15, 1990·Annals of Internal Medicine·L A Rubin, D L Nelson
Apr 1, 1989·Clinics in Dermatology·J C Bystryn
Sep 1, 1989·International Journal of Dermatology·A Mohammad
Oct 1, 1987·Journal of Cellular Physiology·P S Friedmann, B A Gilchrest
May 1, 1986·Journal of the American Academy of Dermatology·R M HalderJ A Kenney
Jul 14, 1973·Lancet·R Hoover, J F Fraumeni
Aug 1, 1971·The American Journal of Medicine·A B Lerner
Aug 1, 1994·International Journal of Dermatology·J S Pasricha, V Khera
Aug 1, 1993·Experimental Dermatology·I C Le PooleW Westerhof
Jul 1, 1996·Journal of the American Academy of Dermatology·P E GrimesA Vojdani
Jan 1, 1997·Dermatologic Clinics·J J Nordlund, P P Majumder
Dec 24, 1997·Clinics in Dermatology·J Castanet, J P Ortonne
Dec 24, 1997·Clinics in Dermatology·J C Bystryn
Jun 4, 1998·The Journal of Dermatology·Y NiheiF Kaneko
Sep 18, 1998·The Journal of Investigative Dermatology·S ReitamoA I Lauerma
Oct 11, 2002·Annals of Surgical Oncology·Francine TremblaySarkis Meterissian
Mar 8, 2003·Pigment Cell Research·Katia OngenaeJean-Marie Naeyaert
Apr 26, 2003·Photodermatology, Photoimmunology & Photomedicine·J P Castanedo-CazaresB Moncada
May 21, 2003·Archives of Dermatology·Veronica LepeAntonio B Torres-Rubalcava

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Citations

Oct 24, 2013·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·U R Hengge
May 13, 2006·Archives of Dermatological Research·Ayca Cordan YaziciUmit Tursen
Sep 30, 2008·Archives of Dermatological Research·Ali-Mohammad NamianEskandar Kamali-Sarvestani
Aug 6, 2013·American Journal of Clinical Dermatology·Carlos R Camara-Lemarroy, Julio C Salas-Alanis
Oct 11, 2005·Journal of Feline Medicine and Surgery·Janet FoleyNiels C Pedersen
Jun 20, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mitesh DwivediRasheedunnisa Begum
Feb 14, 2014·Science Translational Medicine·Mehdi RashighiJohn E Harris
Dec 19, 2012·Indian Journal of Dermatology·Amrinder Jit Kanwar, M Sendhil Kumaran
Aug 17, 2014·Fitoterapia·Yiping ZhuAie Xu
Nov 20, 2015·Pigment Cell & Melanoma Research·Hyejung JungEok-Soo Oh
Aug 16, 2011·Journal of the American Academy of Dermatology·Lesley M FelstenVesna Petronic-Rosic
Jun 1, 2010·Dermatologic Clinics·Andrew N Lin
Nov 26, 2009·The Medical Clinics of North America·Paul T Rose
Feb 10, 2009·Medical Hypotheses·Yajie LvTianwen Gao
Nov 25, 2011·The Journal of Investigative Dermatology·Fengying Shi, Gisela F Erf
Oct 17, 2012·The Journal of Investigative Dermatology·Thierry Passeron, Jean-Paul Ortonne
Feb 14, 2006·The Journal of Investigative Dermatology·Karin LoserStefan Beissert
Nov 22, 2008·Journal of the American Academy of Dermatology·Pinar Y BasakVahide B Akkaya
Jul 31, 2007·Dermatologic Clinics·Torello LottiGionata Buggiani
Jul 27, 2007·Journal of Dermatological Science·Külli KingoSulev Kõks
Aug 30, 2005·Annals of the New York Academy of Sciences·Simon Skurkovich, Boris Skurkovich
Jun 6, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·S RadakovicA Tanew
Mar 25, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·A EryilmazM Baba
Jun 16, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·K M AlGhamdi
Jun 26, 2009·Journal of Clinical Pharmacology·Maha Elgoweini, Nagwa Nour El Din
May 15, 2009·The British Journal of Dermatology·Z A TaherM T Dytoc
Nov 29, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Anke HartmannHenning Hamm
Oct 13, 2006·The British Journal of Dermatology·H Y Kang, Y M Choi
Sep 16, 2008·The Journal of Dermatology·Chong Won ChoiMyeung Nam Kim
Sep 8, 2007·International Journal of Dermatology·Rubens Marcelo Souza Leite, Adriana Aragão Craveiro Leite
Jun 1, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Tobias ForschnerEggert Stockfleth
Oct 24, 2007·Clinical and Experimental Dermatology·M L Dell'AnnaM Picardo
Apr 9, 2008·Dermatologic Therapy·Torello LottiSilvia Moretti
Jul 31, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·D FaiG A Vena
Apr 12, 2007·Clinical and Experimental Dermatology·M Rodríguez-MartínA Noda-Cabrera
Sep 8, 2011·The Journal of Dermatology·Du JuanZhang Jianzhong
Dec 19, 2012·Dermatologic Therapy·Igor V Korobko
Jun 1, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·J ShinS H Oh
Nov 19, 2011·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Tae Seok OhChil Hwan Oh

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