PMID: 16508602Mar 2, 2006Paper

Topical tacrolimus treatment for ocular cicatricial pemphigoid

Annales de dermatologie et de vénéréologie
J-L Michel, Ph Gain

Abstract

Ocular involvement in cicatricial pemphigoid often occurs from the onset. Certain forms are seen only in this condition. A 31-year-old woman presented highly inflammatory conjunctivitis for several months associated with bilateral symblepharons and superficial punctuate keratitis around the left eye refractory to treatment. The patient had a history of mouth ulcers and sores on the scalp. Examination showed scalp lesions with crusts. Histological examination of these lesions revealed dermal-epidermal cleavage. Direct immunofluorescence showed sub-membrane deposits. Anti-basal membrane antibodies were positive. Immunotransfer confirmed the presence of circulating antibodies. This condition was controlled following administration of three courses of cyclophosphamide as a bolus. However, the symblepharons persisted in both eyes. Improvement lasted 4 years. The patient again consulted for inflammatory conjunctivitis and superficial punctate keratitis resulting in invalidating loss of visual acuity, associated with hypereosinophilia. Cortisone eye drops alone resulted in no improvement. Treatment was initiated with topical tacrolimus (Protopic) 0.03% comprising once-daily application to the conjunctiva in the evening. This therapy w...Continue Reading

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Mar 14, 2017·Eye and Vision·Samir S Shoughy
Mar 9, 2018·Ocular Immunology and Inflammation·Lina MaC Stephen Foster
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Jul 17, 2021·Current Opinion in Allergy and Clinical Immunology·Samir JabbourSajjad Ahmad

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