Topical therapies for knee osteoarthritis

Postgraduate Medicine
E C Rodriguez-Merchan

Abstract

Symptomatic knee osteoarthritis (OA) involves millions of adults around the world. To analyze the effectiveness and tolerability of topical therapies and their contemporary placement in knee OA management criteria. A Cochrane Library and PubMed (MEDLINE) search related to the role of topical therapies in knee OA was carried out. Many types of local therapy have been reported, including nonsteroidal anti-inflammatory drugs (NSAIDs) like diclofenac and ketoprofen; capsaicin, cream containing glucosamine sulfate, chondroitin sulfate, and camphor; nimesulide; civamide cream 0.075%; menthol; drug-free gel containing ultra-deformable phospholipid vesicles (TDT 064); 4Jointz utilizing Acteev technology; herbal therapies; gel of medical leech (Hirudo medicinalis) saliva extract; and gel prepared using Lake Urmia mud. One systematic review showed that topical diclofenac and topical ketoprofen can alleviate pain. However, another systematic review found that topical diclofenac and ketoprofen had limited efficacy in knee OA at 6 to 12 weeks. Many studies with a low level of evidence have reported some pain mitigation using the rest of aforementioned topical therapies. Although some controversy exists on the role of topical NSAIDs, current...Continue Reading

References

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Citations

Jun 18, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Chen LiJi Qu
Oct 3, 2019·Medicine·Qinguang XuXiang Wang
Aug 6, 2020·Korean journal of anesthesiology·Eunjoo ChoiJihun Jo
Aug 11, 2020·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hideki TanabeKunihiko Hayashi
Aug 12, 2021·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Varah YuenyongviwatBoonsin Tangtrakulwanich

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