Topical therapies for rheumatoid arthritis by gel ointments containing indomethacin nanoparticles in adjuvant-induced arthritis rat

Journal of Oleo Science
Noriaki NagaiYoshimasa Ito

Abstract

Indomethacin (IMC), a nonsteroidal anti-inflammatory drug, has been used in the treatment of rheumatoid arthritis (RA), although its clinical use has been limited by its systemic side effects that include gastrointestinal lesions. Therefore, the development of IMC formulations that do not cause gastrointestinal lesions is highly anticipated. In this study, we designed new topical formulations containing IMC solid nanoparticles (IMCnano gel ointment), and investigated their pharmacokinetics. In addition, we demonstrate the preventive effects of this topical application of IMC nanoparticles on inflammation in adjuvant-induced arthritis rat (AA rat). The IMCnano gel ointment was prepared using Bead Smash 12 (a bead mill) and additives including 2-hydroxypropyl-β-cyclodextrin, methylcellulose and Carbopol 934; the mean particle size of the IMC nanoparticles was 173 ± 91 nm (means ± S.D.). The application of the IMCnano gel ointment attenuated the increase in paw edema of the hind feet of AA rats in comparison with AA rats treated with gel ointment containing IMC microparticles (IMCmicro gel ointment, particle diameter 17.1 ± 11.6 mm, means ± S.D). In addition, the accumulation of IMC from the IMCnano gel ointment in skin tissue was...Continue Reading

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Citations

May 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sanam DolatiMehdi Yousefi
May 18, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Samira JafariKhosro Adibkia
Nov 11, 2016·Journal of Oleo Science·Noriaki NagaiYoshimasa Ito
Sep 15, 2017·International Journal of Molecular Sciences·Noriaki NagaiNaoki Yamamoto
Jan 5, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Noriaki NagaiNaoya Okamoto
Jan 27, 2019·International Journal of Molecular Sciences·Miyu IshiiNoriaki Nagai
Jul 28, 2019·International Journal of Molecular Sciences·Noriaki NagaiNaohito Kawasaki
Dec 16, 2017·International Journal of Molecular Sciences·Saori DeguchiNoriaki Nagai
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sourav ThakurVijay Mishra
Jan 24, 2020·Journal of Pharmacopuncture·Disha KesharwaniSwarnali Das Paul

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