Topical therapies for the treatment of cervical intraepithelial neoplasia (CIN) 2-3: A narrative review

Gynecologic Oncology Reports
Nerlyne DesravinesLisa Rahangdale

Abstract

Current management of Cervical Intraepithelial Neoplasia (CIN), caused by high-risk human papillomavirus (hr-HPV), is based on surveillance and surgical therapy. Procedures carry potential risks such as preterm birth, and access remains limited throughout the world. However, there are no medical therapies recommended to promote the clearance of hr-HPV infection or CIN. Ultimately, even if less efficacious than excision procedures, medical therapies have the potential to decrease cervical cancer by eliminating barriers to treatment, such as access to treatment, or serving as an adjunct to surgical treatment in both high- and low-resource settings. This review describes current research on topical therapies with the potential for self-application for the treatment of HPV or CIN. Therapies included are immune-modulators, anti-proliferative medications, antivirals, hormones, and herbal/alternative therapies. Randomized trials of immune-modulating (imiquimod), anti-proliferative (5-fluorouracil), and anti-viral (cidofovir) therapies have had the most promising results. However, no option has sufficient clinical trial evidence to be recommended as treatment for CIN 2-3 and surgery remains the standard of care. The research described ...Continue Reading

Citations

Apr 24, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Louise FerrallT-C Wu

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
biopsies
biopsy

Clinical Trials Mentioned

NCT03196180

Software Mentioned

NLM
Emtree

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