PMID: 59189Jul 17, 1976

Topical therapy of ulcerative herpetic keratitis with human interferon

B R JonesK Cantell


55 patients with dendritic ulcer have been treated in a double-blind randomised manner by minimal wiping debridement of their ulcers followed by daily application of either partially purified human interferon (P.I.N.F.) or placebo. There were 6 recurrences of epithelial herpetic disease in 30 patients who received P.I.N.F. and 13 in 25 who received placebo. This provides the long-awaited data proving the antiviral effect of exogenous interferon in treatment of naturally occurring viral disease in man, and furnishes a sighting shot on the lower edge of the target of effective therapy.


Jul 17, 1978·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·R SundmacherD Neumann-Haefelin
Nov 30, 1978·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·R SundmacherD Neumann-Haefelin
Sep 18, 1977·Blut·H Strander
Jan 1, 1994·Biotherapy·N B Finter
Aug 1, 1984·European Journal of Clinical Microbiology·P G Higgins
Nov 1, 1980·Indian Journal of Pediatrics·S Bogger-Goren, P L Ogra
Jan 1, 1980·Pharmacology & Therapeutics·W M Shannon, F M Schabel
Jun 2, 1977·The New England Journal of Medicine·G Wadell
May 4, 1978·The New England Journal of Medicine·T C MeriganR P Fried
Apr 19, 1979·The New England Journal of Medicine·P D Stolley, J L Davies
Apr 24, 1980·The New England Journal of Medicine·M S Hirsch, M N Swartz
May 1, 1979·Antimicrobial Agents and Chemotherapy·C S CrumpackerM J Levin
Jun 1, 1979·The British Journal of Ophthalmology·D J CosterJ I McGill
Aug 1, 1982·The British Journal of Ophthalmology·E W de KoningK Cantell
Jun 1, 1984·The British Journal of Ophthalmology·S O HungP J Rees
Jun 28, 1980·British Medical Journal·G M Scott, D A Tyrrell
Sep 1, 1979·Journal of Clinical Pathology·M C Timbury, E Edmond
Oct 1, 1983·Japanese Journal of Medical Science & Biology·S Yamazaki
Jun 1, 1986·International Journal of Dermatology·Q S Ringenberg, P C Anderson
Apr 17, 2015·The Cochrane Database of Systematic Reviews·K R Wilhelmus
Jan 1, 1982·Journal of Interferon Research·S F LyonsM Crespi
Oct 1, 1982·Medicinal Research Reviews·Z E Dziewanowska, S Pestka
Feb 1, 1983·Australian Journal of Ophthalmology·D J Coster, R D Grutzmacher
Dec 1, 2007·Nature Reviews. Drug Discovery·Ernest C BordenGeorge R Stark
Jun 1, 1980·European Journal of Clinical Investigation·D A Tyrrell
Aug 1, 1982·Acta Ophthalmologica·K B JensenF Jessen

Related Concepts

Administration, Topical
Clinical Trials
Corneal Ulcer
Drug Evaluation
Keratitis, Dendritic

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Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology
R SundmacherK Cantell
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