Topical therapy with rhubarb navel plasters in patients with chronic constipation: Results from a prospective randomized multicenter study.

Journal of Ethnopharmacology
Lin WeiMeizhen Lin

Abstract

Constipation is a functional gastrointestinal disorder and one of the most prevalent conditions encountered in primary care settings. Rhubarb navel dressings have been used for more than 2,000 years in Chinese medicine to treat constipation. However, the effect of topical rhubarb administration has still not been well recognized and this strategy is not yet established as an evidence-based approach. In this study, we performed a prospective multicentric randomized controlled trial to evaluate the efficacy and safety of rhubarb navel plasters for patients with chronic constipation. A total of 374 patients from six teaching hospitals were prospectively included between 09/2016 and 10/2017 in the study based on Rome III criteria. All participants were randomly assigned (1:1) into verum/placebo group and given either Rheum officinale rhubarb powder or a placebo flour stick on the navel for 6 h/day/8 days. Primary outcome measures were the Cleveland Constipation Score (CCS) for the feces condition and Bristol Stool Scale (BSS) for stool consistency and 24 h defecation frequency. The groups demonstrated no statistical differences in demographic data, clinical diagnoses and concomitant medication at baseline. In patients treated with ...Continue Reading

References

Jun 1, 1996·Diseases of the Colon and Rectum·F AgachanS D Wexner
Sep 23, 1997·Scandinavian Journal of Gastroenterology·S J Lewis, K W Heaton
Jul 24, 2004·Adolescent Medicine Clinics·Nader N YoussefCarlo Di Lorenzo
Dec 29, 2004·Journal of Pharmaceutical and Biomedical Analysis·Shao-Wen Sun, Pei-Chen Yeh
Mar 24, 2005·The American Journal of Gastroenterology·Davendra Ramkumar, Satish S C Rao
Mar 9, 2011·Best Practice & Research. Clinical Gastroenterology·J Tack
May 25, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J TackM Fried
Apr 17, 2012·Journal of Ethnopharmacology·Maan Bahadur RokayaKrishna Ram Bhattarai
Dec 18, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R E BurgellS M Scott
Dec 25, 2012·Gastroenterology·Adil E BharuchaG Richard Locke
Dec 7, 2013·Journal of Cosmetic Dermatology·Bruno Burlando, Laura Cornara
Oct 10, 2015·Current Gastroenterology Reports·Hani Sbahi, Brooks D Cash
Apr 2, 2016·Nature Reviews. Gastroenterology & Hepatology·Satish S C RaoTanisa Patcharatrakul
Jun 15, 2017·World Journal of Gastroenterology : WJG·Jun LiZong-Fang Li
Jul 25, 2017·Journal of Neurogastroenterology and Motility·Veeravich JaruvongvanichSutep Gonlachanvit
Nov 21, 2017·Internal Medicine·Kentaro ShimizuTakeshi Shimazu
May 15, 2018·Frontiers in Pharmacology·Dongqing GuoXing Chen
Dec 15, 2018·Journal of Gastroenterology and Hepatology·Meng-Rui ChenZhi-Huan Zhou

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