Topical timolol solution versus laser in treatment of infantile hemangioma: a comparative study

Pediatric Dermatology
Abeer A Tawfik, Jehan Alsharnoubi

Abstract

Lasers, 595-nm pulsed dye and 1,064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG), have been used successfully for the treatment of infantile hemangiomas (IHs). Recently the use of a topical β-blocker, specifically timolol maleate, has been promising in the treatment of IHs. The objective of this study was to compare the effectiveness of topical timolol 5 mg/mL solution with that of combined sequential dual-wavelength laser in the treatment of IHs. Sixty children with IHs were divided randomly into two equal groups. Group 1 was treated with applications of timolol drops (5 mg/mL) twice daily. Group 2 was treated with sequential pulsed dye and Nd:Yag laser. Treatments were performed every month for a maximum of six sessions. Efficacy was evaluated clinically and by measuring the average hemoglobin level. A significant decrease in the average hemoglobin level was determined in both groups and a dramatic response was observed in superficial hemangiomas in the timolol group. The timolol group received treatment for an average of 4.0 ± 1.1 months and the laser group for 5.5 ± 0.9 months. The degree of improvement of mixed hemangiomas to laser treatment was greater than that of the timolol group. During 3 months of follow-up, n...Continue Reading

References

Apr 24, 2008·Pediatric Dermatology·Christine Kilcline, Ilona J Frieden
Jan 20, 2012·Pediatric Dermatology·Patrick McMahonIlona J Frieden
Jun 27, 2012·Clinical and Experimental Dermatology·K Semkova, J Kazandjieva
May 25, 2013·The British Journal of Dermatology·M Luu, I J Frieden

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Citations

Dec 30, 2015·Lasers in Surgery and Medicine·Sivakumar ChinnaduraiTanya Surawicz
Apr 19, 2018·The Cochrane Database of Systematic Reviews·Monica NovoaIngrid Arevalo-Rodriguez
Jan 25, 2018·Archives of Dermatological Research·Lei Zheng, Yunling Li
Sep 10, 2015·British Journal of Hospital Medicine·Sue Ann Chan, Helen M Goodyear
Nov 11, 2018·The British Journal of Dermatology·M NovoaI Arevalo-Rodriguez
Jul 15, 2020·International Journal of Dermatology·Hao YangXiao-Dong Guo
May 10, 2020·Current Pediatric Reviews·Alexander K C LeungKam L Hon
Oct 8, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Xinhui WangLiang Dong
Jan 17, 2016·Pediatrics·Sivakumar ChinnaduraiMelissa L McPheeters

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