Topical Treatment of Degenerative Knee Osteoarthritis

The American Journal of the Medical Sciences
Zengdong Meng, Rongzhong Huang

Abstract

This article reviews topical management strategies for degenerative osteoarthritis (OA) of the knee. A search of Pubmed, Embase and the Cochrane library using MeSH terms including "topical," "treatment," "knee" and "osteoarthritis" was carried out. Original research and review articles on the effectiveness and safety, recommendations from international published guidelines and acceptability studies of topical preparations were included. Current topical treatments included for the management of knee OA include topical nonsteroidal anti-inflammatory drugs, capsaicin, salicylates and physical treatments such as hot or cold therapy. Current treatment guidelines recommend topical nonsteroidal anti-inflammatory drugs as an alternative and even first-line therapy for OA management, especially among elderly patients. Guidelines on other topical treatments vary, from recommendations against their use, to in favor as alternative or simultaneous therapy, especially for patients with contraindications to other analgesics. Although often well-tolerated and preferred by many patients, clinical care still lags in the adoption of topical treatments. Aspects of efficacy, safety and patient quality of life data require further research.

References

Jun 1, 1995·Arthritis and Rheumatism·E F PhilbinT E Miller
Jun 14, 2003·The Cochrane Database of Systematic Reviews·L BrosseauP Tugwell
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Dec 3, 2003·Annals of the Rheumatic Diseases·K M JordanUNKNOWN Standing Committee for International Clinical Studies Including Therapeutic Trials ESCISIT
Mar 9, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Consuelo HuertaLuis Alberto García Rodríguez
May 17, 2005·American Journal of Preventive Medicine·Matthew T McKennaJames S Marks
Apr 4, 2006·Arthritis and Rheumatism·David A GanzCatherine H MacLean
Feb 7, 2007·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Patricia Katz, Fleur Lee
May 2, 2009·The American Journal of Cardiology·Michael E Farkouh, Bruce P Greenberg
Jul 4, 2009·Journal of the American Geriatrics Society·UNKNOWN American Geriatrics Society Panel on Pharmacological Management of Persistent Pain in Older Persons
Nov 26, 2009·Seminars in Arthritis and Rheumatism·H Richard BarthelRoy D Altman
Jan 6, 2010·Cleveland Clinic Journal of Medicine·Amy SchillingBijan Eghtesad
Aug 12, 2010·Clinics in Geriatric Medicine·David J Hunter
Aug 17, 2010·Clinical Interventions in Aging·Craig R DenegarWilliam J Kraemer
Dec 21, 2010·Rheumatology·Vijitha De SilvaUNKNOWN Arthritis Research UK Working Group on Complementary and Alternative Medicines
Feb 8, 2011·British Journal of Sports Medicine·David J Hunter
Jul 21, 2011·Drugs·Roy D Altman, H Richard Barthel
Mar 7, 2012·Arthritis and Rheumatism·Richard F LoeserMary B Goldring
Dec 4, 2012·Arthritis Care & Research·Elena LosinaJeffrey N Katz
Apr 19, 2013·Annals of the Rheumatic Diseases·Linda FernandesUNKNOWN European League Against Rheumatism (EULAR)
May 25, 2013·The Physician and Sportsmedicine·Stephen A Klinge, Gregory A Sawyer
Jan 1, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Mary Lynn McPherson, Nina M Cimino
Jan 28, 2014·Osteoarthritis and Cartilage·T E McAlindonM Underwood
May 6, 2014·Best Practice & Research. Clinical Rheumatology·Victoria L Johnson, David J Hunter
Feb 27, 2015·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·UNKNOWN American College of Medical Toxicology
Nov 26, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Paul A SchmeltzerUNKNOWN Drug-Induced Liver Injury Network (DILIN)
Jan 6, 2016·Pediatrics in Review·Ellie E Rakovchik, Daniel M Fein

❮ Previous
Next ❯

Citations

Aug 30, 2018·Postgraduate Medicine·E C Rodriguez-Merchan
Aug 11, 2020·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hideki TanabeKunihiko Hayashi
Apr 29, 2021·Journal of Orthopaedic Surgery and Research·Kevin Ki-Wai HoJack Chun-Yiu Cheng
Jan 6, 2019·ACS Applied Materials & Interfaces·Viviana P RibeiroRui L Reis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.