Topical treatments for pain

Current Pain and Headache Reports
Charles E Argoff

Abstract

Topical analgesics exert their analgesic benefit locally and without significant systemic absorption. The mechanism of the topical analgesic is unique to the specific medication. Key differences between topical and transdermal analgesics are discussed in this article. A new term, targeted peripheral analgesics, has been suggested to replace the term topical analgesics, but is not in widespread use. Topical analgesics have been studied in an increasing number of painful clinical conditions; the results of many of these studies are summarized in this review. Recent data suggest that at least one topical analgesic, although applied peripherally, may result in central nervous system alterations of pain processing.

References

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Citations

Feb 28, 2006·Current Pain and Headache Reports·Charles E Argoff
Aug 7, 2012·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Yong-Soon KwonKyong Shil Im
Sep 10, 2015·Drug Delivery and Translational Research·Ali Aghazadeh-HabashiMichael R Doschak
Mar 17, 2010·Pain Practice : the Official Journal of World Institute of Pain·Joseph V PergolizziAaron Tabor
Aug 25, 2017·The International Journal of Lower Extremity Wounds·Anne PurcellAndrea P Marshall
Apr 12, 2017·EMBO Molecular Medicine·Shu WangJianru Xiao

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