Topical tretinoin, another failure in the pursuit of practical chemoprevention for non-melanoma skin cancer

The Journal of Investigative Dermatology
Peggy A Wu, Robert S Stern

Abstract

Given the high incidence of non-melanoma skin cancer (NMSC), a preventative intervention would be desirable. Except for regular sunscreen use, the quest for chemoprevention of NMSC in the general population has been unsuccessful. Weinstock et al. assessed the effects of 0.1% topical tretinoin on NMSC. Like earlier efforts at chemoprevention, this study failed to show therapeutic benefit. Future successful preventative strategies will likely rely on short-term, intermittent therapy or treatments used for other common indications.

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Citations

Sep 30, 2015·Experimental and Molecular Pathology·Helen B EvertsJohn P Sundberg
Oct 10, 2015·Future Oncology·Tiago Ribeiro Correia de SáJosé Manuel Lopes
Feb 27, 2015·Photochemistry and Photobiology·Katherine L GresselHelen B Everts
Dec 30, 2014·Molecular Aspects of Medicine·Alessandra di MasiClara Nervi
Mar 8, 2013·Dermato-endocrinology·Fragkiski TsatsouDimitrios Sotiriadis
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Jan 25, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P SeverinoE B Souto
Dec 4, 2019·Anais Brasileiros De Dermatologia·Clarissa Prieto Herman Reinehr, Renato Marchiori Bakos

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