Topical use of dexpanthenol: a 70th anniversary article

The Journal of Dermatological Treatment
E ProkschStéphanie Boudon

Abstract

Approximately 70 years ago, the first topical dexpanthenol-containing formulation (Bepanthen™ Ointment) has been developed. Nowadays, various topical dexpanthenol preparations exist, tailored according to individual requirements. Topical dexpanthenol has emerged as frequently used formulation in the field of dermatology and skin care. Various studies confirmed dexpanthenol's moisturizing and skin barrier enhancing potential. It prevents skin irritation, stimulates skin regeneration and promotes wound healing. Two main directions in the use of topical dexpanthenol-containing formulations have therefore been pursued: as skin moisturizer/skin barrier restorer and as facilitator of wound healing. This 70th anniversary paper reviews studies with topical dexpanthenol in skin conditions where it is most frequently used. Although discovered decades ago, the exact mechanisms of action of dexpanthenol have not been fully elucidated yet. With the adoption of new technologies, new light has been shed on dexpanthenol's mode of action at the molecular level. It appears that dexpanthenol increases the mobility of stratum corneum molecular components which are important for barrier function and modulates the expression of genes important for w...Continue Reading

References

Jan 1, 1991·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·W HosemannI Dunker
Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·B LacroixJ F Grenier
Mar 10, 1969·The Journal of Vitaminology·Y AbikoM Shimizu
May 1, 1993·The British Journal of Dermatology·E ProkschK R Feingold
Dec 1, 1995·Free Radical Biology & Medicine·V S SlyshenkovL Wojtczak
Apr 28, 1999·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·B I Weimann, D Hermann
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Jan 31, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·N K KuşcuS Laçin
Jul 27, 2002·Plastic and Reconstructive Surgery·Thomas A MustoeUNKNOWN International Advisory Panel on Scar Management
May 14, 2004·Current Medical Research and Opinion·David J Atherton
Jul 16, 2005·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Kristine Morland-Schultz, Pamela D Hill
Dec 21, 2006·European Journal of Pediatrics·Helmut H Wolff, Meinhard Kieser
Jan 12, 2008·The Australasian Journal of Dermatology·Dan SlodownikRosemary Nixon
Jan 12, 2008·Skin Pharmacology and Physiology·E Proksch
Jun 19, 2008·Experimental Dermatology·Katrin LorenzAugustinus Bader
Sep 16, 2008·Pediatric Dermatology·Ralf Adam
Oct 28, 2008·Burns : Journal of the International Society for Burn Injuries·Monica C T BloemenEsther Middelkoop
Apr 29, 2009·Experimental Dermatology·Tonio WiederholtJens Malte Baron
Aug 10, 2010·Journal of the American Academy of Dermatology·Eric L SimpsonJon M Hanifin
Jul 5, 2012·Skin Pharmacology and Physiology·R HeiseJ M Baron
Jul 19, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·J RingUNKNOWN Global Allergy and Asthma European Network (GA2LEN)
Nov 28, 2012·Annals of Nutrition & Metabolism·Douglas J Lanska
Aug 21, 2013·The Annals of Otology, Rhinology, and Laryngology·Saban CelebiOner Celik
Nov 15, 2013·Pediatric Dermatology·Georgios N Stamatas, Neena K Tierney
Jul 16, 2014·Clinics in Dermatology·Christopher KlunkKaren Wiss
Oct 6, 2014·The Journal of Allergy and Clinical Immunology·Eric L SimpsonHywel C Williams
Feb 6, 2016·Current Problems in Dermatology·Simon G Danby
Feb 6, 2016·Current Problems in Dermatology·Marie Lodén
Feb 6, 2016·Current Problems in Dermatology·Ana Giménez-Arnau
Jun 18, 2016·International Journal of Dermatology·David J Atherton

❮ Previous
Next ❯

Citations

Jul 11, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Matthias AugustinPetra Staubach
Oct 19, 2019·Archives of Dermatological Research·Hernán CortésGerardo Leyva-Gómez
Nov 7, 2019·Phytotherapy Research : PTR·Alaa A GheitaSanaa A Kenawy
Apr 19, 2019·The Journal of Dermatological Treatment·Ehrhardt ProkschJoke Bouwstra
Nov 19, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Matthias AugustinPetra Staubach
Jul 16, 2020·Advanced Pharmaceutical Bulletin·Artur MartynovOstap Brek
Apr 3, 2020·Progress in Lipid Research·Philippe NaquetRoberta Leonardi
Jul 7, 2021·International Journal of Cosmetic Science·Jonathan M Crowther
Sep 16, 2021·Dermatitis : Contact, Atopic, Occupational, Drug·Yujie Linda LiouErin M Warshaw
Dec 13, 2018·Journal of Ophthalmology·Islam Mahmoud Hamdi
Jan 20, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Jens Malte BaronEhrhardt Proksch
Nov 24, 2021·International Journal of Cosmetic Science·Marta S FerreiraIsabel F Almeida

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.