Topical Use of Quercetin-Loaded Chitosan Nanoparticles Against Ultraviolet B Radiation

Frontiers in Pharmacology
Wenhao NanXiaojun Shi

Abstract

Ultraviolet radiation is a major risk factor for human skin damage, especially solar ultraviolet-B (UVB) which can induce inflammation, photoaging, and skin cancer. Quercetin (Qu), one of flavonoid family members, has showed protective effects against UVB radiation. However, its application for topical use is limited by low hydrophilicity and poor percutaneous absorption. Herein, we found that Qu, if entrapped into TPP-Chitosan nanoparticles (TCs), can be efficiently uptake by HaCaT cells and easily permeate through the epidermis layer, meanwhile display better stability and low cytotoxicity. We also found that Qu-loaded TCs (QTCs) could notably enhance the effect of Qu on inhibiting the NF-kB/COX-2 signaling pathway as well as ameliorating the skin edema caused by UVB radiation. Therefore, this study provided a method to get rid of Qu's low hydrophilicity, enhance its percutaneous absorption and retention in the skin, and further improve its anti-UVB effect, and demonstrated that Qu-loaded chitosan nanoparticles can be used as the therapeutic agent for topical use against UVB radiation.

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Citations

Jul 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Parinaz SabourianAshok Kakkar
Dec 19, 2018·Frontiers in Pharmacology·Xi GuoChengwei Wang
Nov 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iwona GolonkaWitold Musiał
Aug 28, 2019·Seminars in Cancer Biology·Paola AielloIlaria Peluso
Apr 15, 2020·International Journal of Biological Macromolecules·Hend Abd-AllahMaha Nasr
Apr 20, 2021·Frontiers in Oncology·María Zenaida Saavedra-LeosMacrina Beatriz Silva-Cázares
Jun 16, 2021·Carbohydrate Polymers·Salma A FereigMona M A Abdel-Mottaleb
Aug 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mariana Carolina Di SantoOscar Edgardo Pérez

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Methods Mentioned

BETA
Dynamic Light Scattering
transmission electron microscopy

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