Topical use of tranexamic acid to control perioperative local bleeding in gynaecology patients with clotting disorders: two cases

Haemophilia : the Official Journal of the World Federation of Hemophilia
I SarrisR A Kadir


Operating on patients with abnormal coagulation is a challenge frequently faced by surgeons. Achieving haemostasis perioperatively can involve bleeding points that would not ordinarily present a problem with intact clotting function. Here we present two women with localised wound bleeding following a gynaecological surgery in the presence of a clotting disorder. Haemostasis was successfully achieved with tropical use of tranexamic acid. These two cases illustrate a novel use for this antifibrinolytic agent. We suggest that there is a role for topical use of tranexamic acid in perioperative haemostasis in patients with clotting disorders.


Dec 1, 1977·Fertility and Sterility·P F TauberL J Zaneveld
Nov 10, 2001·The Cochrane Database of Systematic Reviews·D A HenryD Fergusson


Jul 27, 2012·Emergency Medicine Journal : EMJ·Sarah Noble, Jaydeep Chitnis
Aug 3, 2013·The Journal of Arthroplasty·Andrew G GeorgiadisMichael W Laker
Oct 11, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Y M J TangP Brooks
Jul 6, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·M J Coetzee
Sep 10, 2015·The British Journal of Surgery·Kjersti AusenHilde Pleym
Dec 29, 2011·The Annals of Pharmacotherapy·Heather J Ipema, Maria G Tanzi

Related Concepts

Administration, Topical
Plasmin Inhibitor
Blood Coagulation Disorders
Hemophilia B
Uterine Fibroids
Vaginal Prolapse

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.