Topical versus systemic capsaicin desensitization: specific and unspecific effects as indicated by modification or reflex micturition in rats.

Neuroscience
C A MaggiA Meli

Abstract

The aim of this study was to determine the acute and delayed effect of topical application of high concentrations of capsaicin on the rat urinary bladder on micturition reflex and compare the effects of "topical" bladder desensitization with those produced by systemic (subcutaneous administration) capsaicin desensitization. On acute application, capsaicin (1-3%) produced a transient bladder contraction, not observed in capsaicin-pretreated rats. After a transient increase in excitability of the micturition reflex, topical capsaicin suppressed micturition and overflow incontinence ensued which was reverted by intravenous injection of 4-aminopyridine. Topical capsaicin also abolished reflex micturition in rats which had been systemically treated with capsaicin as adults (50 mg/kg, 7 days before) and reduced significantly the neurogenic bladder contractions produced by intravenous dimethylphenylpiperazinium or neurokinin A, while the direct (myogenic) response to neurokinin A was unaffected. In rats whose bladder was pre-exposed to 1-3% topical capsaicin (7 days before) the micturition reflex was affected in a manner which is qualitatively and quantitatively similar to that observed in rats treated with capsaicin as adults, e.g. i...Continue Reading

References

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Citations

Jul 9, 2003·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·S Ahmed, J Yuan
Sep 4, 1990·European Journal of Pharmacology·M TakakiS Nakayama
Sep 1, 1994·Physiology & Behavior·R M Craft, F Porreca
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Dec 3, 2013·Physiology & Behavior·Zita PetrovszkiGyöngyi Horvath
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Mar 22, 2007·American Journal of Physiology. Endocrinology and Metabolism·Satoshi FujitaCasey M Donovan
Jun 22, 2021·American Journal of Physiology. Renal Physiology·Christopher L LangdaleWarren M Grill

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