Topically applied 2-octyl cyanoacrylate (Dermabond) for prevention of postoperative pancreatic fistula after pancreaticoduodenectomy.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Omar BarakatR Patrick Wood

Abstract

We examined whether 2-octyl cyanoacrylate (Dermabond) topically applied to the pancreaticojejunostomy (PJ) anastomotic site after pancreaticoduodenectomy (PD) reduces the rate of postoperative pancreatic fistula (POPF). Patients who underwent PD with duct-to-mucosa PJ were evaluated (n = 124). Outcome was compared between patients who received Dermabond (n = 75) after PD and historic patients who did not (n = 49). Risk factors for POPF were identified. Overall and clinically relevant rates of POPF were significantly lower in patients who received Dermabond than in patients who did not (2.6 % and 1.3 % vs. 22 % and 12 %, respectively; p = 0.001). In univariate analysis, pancreatic duct diameter ≤3 mm, low serum albumin level, and no Dermabond were independent risk factors for POPF; in multivariate analysis, no Dermabond was an independent risk factor for POPF. In patients with pancreatic duct diameter ≤3 mm, the rate of POPF was significantly lower in patients who received Dermabond than in patients who did not (3.5 % versus 36 %, respectively; p = 0.0001). Patients who received Dermabond had significantly shorter hospital stays and lower re-operation and re-admission rates. Topical application of Dermabond to the PJ anastomotic...Continue Reading

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Citations

Aug 27, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Motokazu SugimotoMasaru Konishi
Jan 2, 2016·The Indian Journal of Surgery·Ammar A JavedChristopher L Wolfgang
Jun 6, 2013·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Z WuJ F Lange
Jan 24, 2018·World Journal of Gastrointestinal Surgery·Narongsak RungsakulkijSuraida Aeesoa
Feb 7, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Omar BarakatR Patrick Wood
Apr 11, 2015·Surgery Today·Yoshiyuki SaitoMasaki Kitajima
Apr 22, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Francesca ScognamiglioSergio Paoletti
Mar 4, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Orlin BelyaevWaldemar Uhl
Jan 17, 2017·World Journal of Surgery·Laura-Christin TillmannOrlin Belyaev
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Zixian BaoMo Xian
Apr 27, 2021·Annals of Medicine and Surgery·Francesco SerraRoberta Gelmini
Oct 6, 2021·Khirurgiia·K D DalgatovA V Sazhin

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