Topically applied connective tissue growth factor/CCN2 improves diabetic preclinical cutaneous wound healing: potential role for CTGF in human diabetic foot ulcer healing

Journal of Diabetes Research
F R HenshawS M Twigg

Abstract

Topical application of CTGF/CCN2 to rodent diabetic and control wounds was examined. In parallel research, correlation of CTGF wound fluid levels with healing rate in human diabetic foot ulcers was undertaken. Full thickness cutaneous wounds in diabetic and nondiabetic control rats were treated topically with 1 μg rhCTGF or vehicle alone, on 2 consecutive days. Wound healing rate was observed on day 14 and wound sites were examined for breaking strength and granulation tissue. In the human study across 32 subjects, serial CTGF regulation was analyzed longitudinally in postdebridement diabetic wound fluid. CTGF treated diabetic wounds had an accelerated closure rate compared with vehicle treated diabetic wounds. Healed skin withstood more strain before breaking in CTGF treated rat wounds. Granulation tissue from CTGF treatment in diabetic wounds showed collagen IV accumulation compared with nondiabetic animals. Wound α-smooth muscle actin was increased in CTGF treated diabetic wounds compared with untreated diabetic wounds, as was macrophage infiltration. Endogenous wound fluid CTGF protein rate of increase in human diabetic foot ulcers correlated positively with foot ulcer healing rate (r = 0.406; P < 0.001). These data collect...Continue Reading

References

Dec 1, 1991·Journal of the American Academy of Dermatology·M H KatzV Falanga
May 1, 1993·Plastic and Reconstructive Surgery·D P GreenwaldL J Gottlieb
Oct 20, 1998·American Journal of Surgery·W K StadelmannG R Tobin
May 20, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jian Fei WangDavid A Hart
May 27, 2003·Diabetes Care·Adam GordoisJanet Ash Tobian
Sep 17, 2004·Molecular Biology of the Cell·Yunliang ChenAndrew Leask
Mar 12, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Iwona CichaChristoph D Garlichs
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert D StoutJill Suttles
Nov 18, 2005·Lancet·Vincent Falanga
Jun 24, 2006·Bulletin of Mathematical Biology·Helen V Waugh, Jonathan A Sherratt
Jan 30, 2007·Diabetes Care·Ling XuDennis K Yue
May 17, 2007·British Journal of Community Nursing·Anna Rich
May 17, 2007·British Journal of Community Nursing·Jackie Stephen-Haynes, Louise Toner
Sep 21, 2007·The New England Journal of Medicine·Carmen FonsecaDavid J Abraham
Dec 18, 2007·The Journal of Surgical Research·Haihong LiTongzhu Sun
Dec 2, 2008·Acta Physiologica·A DanielsF A van Nieuwenhoven
Jan 9, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Susan V McLennanStephen M Twigg
Feb 22, 2012·Molecular and Cellular Biochemistry·Jun-Sub KimCheong Hoon Seo
Dec 1, 2012·Experimental Diabetes Research·Raffaele MarfellaSilvestro Canonico
Dec 6, 2012·Laboratory Investigation; a Journal of Technical Methods and Pathology·Maria P AlfaroPampee P Young

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Citations

Apr 23, 2015·Journal of Cell Communication and Signaling·Andrew Leask
Jan 25, 2017·Journal of Functional Biomaterials·Alessandra L MooreMichael T Longaker
Feb 8, 2018·Journal of Cell Communication and Signaling·Stephen M Twigg
Dec 24, 2018·Tissue Engineering. Part a·Christopher G ElliottDouglas W Hamilton
Aug 19, 2015·Nature Reviews. Endocrinology·Frank L BowlingAndrew J M Boulton
Feb 28, 2020·Experimental and Therapeutic Medicine·Yongjian HuangJinsong Xue
May 10, 2017·Journal of Tissue Engineering and Regenerative Medicine·Ashang Luwang LaivaMichael B Keogh
Oct 28, 2019·Advances in Wound Care·Amir Hossein Siadat, Roslyn Rivkah Isseroff
Apr 26, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sungjoo ParkSun Chang Kim
May 5, 2021·Molecular and Cellular Biochemistry·Finosh G ThankamDevendra K Agrawal

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