Topically applied L-carnitine effectively reduces sebum secretion in human skin

Journal of Cosmetic Dermatology
Reto I PeiranoHorst Wenck

Abstract

Oily skin condition is caused by an excessive sebaceous gland activity, resulting in an overproduction of sebum, giving the skin an undesired shiny, oily appearance. To identify an active substance that reduces sebum production in human sebaceous glands by regulating fat metabolism in a natural way. The effects of L-carnitine on β-oxidation and intracellular lipid content were investigated in vitro using the human sebaceous cell line SZ95. Penetration experiments utilizing pig skin as a model system were performed with a cosmetic formulation containing radioactively labeled L-carnitine. To determine the in vivo effects, a vehicle-controlled, randomized study was carried out using a cosmetic formulation containing 2%l-carnitine for 3 weeks. Sebum production was investigated utilizing the lipid-absorbent Sebutape(®). SZ95 cells treated with 0.5% or 1% L-carnitine demonstrated a significant concentration-dependent increase in β-oxidation compared to control cells. Following the treatment with L-carnitine, intracellular lipid concentrations decreased significantly in a dose-dependent manner compared with untreated control cells. In skin penetration experiments, topically applied L-carnitine reached the dermis. In addition, topical ...Continue Reading

References

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Citations

Jun 14, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·I Angelova-FischerD Zillikens
Jul 12, 2016·Journal of Cutaneous and Aesthetic Surgery·Chee Leok GohSu Ni Wong
Feb 27, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sang Ju LeeSeong Jun Seo
Apr 10, 2019·Journal of Cosmetic Dermatology·Pongpaka PongsakornpaisanMayuree Kanlayavattanakul

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