PMID: 7932047Jun 1, 1994Paper

Topically effective ocular hypotensive acetazolamide and ethoxyzolamide formulations in rabbits

The Journal of Pharmacy and Pharmacology
Thorsteinn LoftssonT Sigthórsson

Abstract

The effect of topically active 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) eye-drop formulations containing solutions of acetazolamide, ethoxyzolamide or timolol on the intra-ocular pressure (IOP) was investigated in normotensive conscious rabbits. Both acetazolamide and ethoxyzolamide were active but their IOP-lowering effect was less than that of timolol. The IOP-lowering effects of acetazolamide and ethoxyzolamide and that of timolol appeared to be to some extent additive. Combination of acetazolamide and timolol or ethoxyzolamide and timolol in one HP-beta-CyD formulation resulted in a significant increase in the duration of activity compared with HP-beta-CyD formulations containing only acetazolamide, ethoxyzolamide or timolol. Also, it was possible to increase the IOP-lowering effect of acetazolamide by formulating the drug as a suspension in an aqueous HP-beta-CyD vehicle.

References

Jul 1, 1985·Archives of Ophthalmology·Z FriedmanS M Raph

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·T Loftssona, T Järvinen
May 10, 2000·International Journal of Pharmaceutics·I P KaurM Kanwar
Aug 8, 2001·International Journal of Pharmaceutics·T Loftsson, M Masson
Nov 14, 2002·International Journal of Pharmaceutics·Indu Pal KaurMona Kapil
Apr 16, 2002·Acta Ophthalmologica Scandinavica·Thorsteinn Loftsson, Einar Stefánsson
Jun 14, 2003·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Sigrid KnappUwe Pleyer
Sep 23, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Junjie ZhangHuiyun Xia
Nov 27, 2004·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Eckart Bertelmann, Uwe Pleyer
Apr 6, 2007·AAPS PharmSciTech·Rania M HathoutAhmed S Guinedi
Apr 1, 2010·Journal of Pharmacy & Bioallied Sciences·Gaurav TiwariAwani K Rai
Nov 22, 2005·Expert Opinion on Drug Delivery·Thorsteinn LoftssonTomi Järvinen
Jul 31, 2012·Toxicology and Applied Pharmacology·Neera Tewari-SinghRajesh Agarwal
Nov 27, 2004·The Journal of Pharmacy and Pharmacology·Deepika AggarwalIndu P Kaur
Aug 16, 2005·International Journal of Pharmaceutics·Thorsteinn LoftssonMár Másson
Sep 24, 2013·Carbohydrate Polymers·M J García-FernándezC Alvarez-Lorenzo
Mar 15, 2011·Therapeutic Delivery·Uday B KompellaVincent H L Lee
Nov 3, 2005·International Journal of Pharmaceutics·Ahmed S GuinediRania M Hathout
Apr 10, 2017·International Journal of Pharmaceutics·Thorsteinn Loftsson, Einar Stefánsson
Oct 26, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·B SiefertS Keipert
Dec 12, 2019·Advances in Therapy·Marcelo Luís OcchiuttoAnastasios G Konstas
Aug 11, 2011·The Journal of Pharmacy and Pharmacology·Thorsteinn Loftsson, Marcus E Brewster
Jan 25, 2012·Acta Ophthalmologica·Thorsteinn LoftssonEinar Stefánsson
Nov 1, 1996·Journal of Pharmaceutical Sciences·R A Rajewski, V J Stella
Aug 1, 2021·International Journal of Pharmaceutics·Phatsawee JansookEinar Stefánsson

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