Topiramate as a rare cause of reversible Fanconi syndrome and acute kidney injury: a case report and literature review

Journal of Community Hospital Internal Medicine Perspectives
Marcelle G MeseehaVictor O Kolade

Abstract

Topiramate (TPM) is a sulfa-derivative monosaccharide that has been used for multiple indications in the last several years. We describe a 53-year-old woman with known chronic kidney disease stage 2 and baseline creatinine of 1 mg/dL who developed acute kidney injury and proximal renal tubular dysfunction while on TPM for depression. The Naranjo Adverse Drug Reaction Probability Scale indicated a probable relationship (score of 6) between TPM and acute kidney injury as well as proximal tubular dysfunction; these renal conditions resolved on withdrawal of TPM. To our knowledge, this is the first report of such a scenario. Patients receiving TPM therapy should be closely monitored for evidence of kidney dysfunction and electrolyte abnormalities.

References

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Nov 18, 2009·British Journal of Clinical Pharmacology·Nasir MirzaMunir Pirmohamed
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Jun 23, 2015·International Journal of Applied & Basic Medical Research·Jagjit Singh, Rajiv Kumar

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BETA
electrophoresis
biopsy

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