Topiramate does not alter nicotine or cocaine discrimination in rats

Behavioural Pharmacology
Bernard Le FollSteven R Goldberg

Abstract

The effects of topiramate, a potential treatment for drug dependence, were evaluated in two groups of rats trained to discriminate the administration of either 0.4 mg/kg nicotine or 10 mg/kg cocaine from that of saline, under a fixed-ratio 10 schedule of food delivery. Topiramate (1-60 mg/kg, intraperitoneal) did not produce any nicotine-like or cocaine-like discriminative effects by itself and did not produce any shift in the dose-response curves for nicotine or cocaine discrimination. Thus, the ability to discriminate the effects of nicotine or cocaine does not appear to be altered by topiramate administration. Furthermore, topiramate, given either alone or in combination with nicotine or cocaine, did not depress rates of responding. These experiments indicate that topiramate does not enhance or reduce the ability of rats to discriminate the effects of nicotine or cocaine.

References

Jan 1, 1987·British Journal of Pharmacology·R KumarI P Stolerman
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·W A Corrigall, K M Coen
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·P M CallahanK A Cunningham
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·R D SpealmanT V Khroyan
Jul 6, 2000·European Psychiatry : the Journal of the Association of European Psychiatrists·B Le FollP Sokoloff
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Daniele F ZullinoJacques Besson
Mar 1, 2003·Molecular Psychiatry·B Le FollP Sokoloff
Oct 15, 2003·The Journal of Pharmacology and Experimental Therapeutics·Zuzana JustinovaSteven R Goldberg
Jan 30, 2004·Pharmacopsychiatry·G RubioF Ferre
Apr 29, 2004·Alcoholism, Clinical and Experimental Research·Bankole A JohnsonRobert J Malcolm
May 4, 2004·Trends in Pharmacological Sciences·Paul J Kenny, Athina Markou
May 21, 2004·Nature Reviews. Neuroscience·Roy A Wise
Jul 31, 2004·Drug and Alcohol Dependence·Kyle M KampmanCharles P O'Brien
Aug 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caroline CohenPhilippe Soubrié
Oct 16, 2004·Neuroreport·Bernard Le Foll, Steven R Goldberg
Nov 5, 2004·The Journal of Pharmacology and Experimental Therapeutics·Bernard Le Foll, Steven R Goldberg
Nov 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bernard Le FollSteven R Goldberg
Apr 28, 2005·Expert Review of Neurotherapeutics·Bankole A Johnson
May 27, 2005·Journal of Medicinal Chemistry·Amy Hauck NewmanMichael A Nader
Jun 1, 2005·Trends in Pharmacological Sciences·Bernard Le Foll, Steven R Goldberg
Jun 21, 2005·Neuropharmacology·Bernard Le FollPierre Sokoloff
Jul 6, 2005·Epilepsy & Behavior : E&B·Mariam AlaverdashviliPavel Mares
Jul 27, 2005·Archives of Internal Medicine·Bankole A JohnsonMartin A Javors
Aug 20, 2005·European Journal of Pharmacology·Bernard Le Foll, Steven R Goldberg
Nov 15, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Amani EltaybTorgny H Svensson
Jan 25, 2006·Psychopharmacology·Mehmet SofuogluThomas Kosten
Feb 2, 2006·The International Journal of Neuropsychopharmacology·Bankole A JohnsonXin-Qun Wang
Mar 17, 2006·Current Psychiatry Reports·Joseph F Cubells
Apr 15, 2006·CNS & Neurological Disorders Drug Targets·P SokoloffC Gross
Apr 28, 2006·Current Opinion in Psychiatry·Frank J Vocci, Ahmed Elkashef

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Citations

Oct 28, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yijin YanBernard Le Foll
Mar 6, 2010·Annals of the New York Academy of Sciences·Heath D Schmidt, R Christopher Pierce

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