Topiramate for cocaine dependence: a systematic review and meta-analysis of randomized controlled trials

Addiction
Mohit SinghDan Werb

Abstract

To assess the efficacy of topiramate in treating cocaine use disorder (i.e. retention, efficacy, safety and craving reduction) through a systematic review and meta-analysis. We searched six scientific databases from inception to 23 December 2014 with no date limits. Data were reviewed, extracted and analysed systematically. Studies were included if they were peer-reviewed randomized control trials with participants meeting diagnostic criteria for cocaine dependence or cocaine use disorder, with the treatment arm involving topiramate with or without psychosocial intervention, and the control arm involving no intervention or psychosocial intervention with or without placebo. A random-effects meta-analytical model was computed. Five studies met inclusion criteria (n = 518). Topiramate was compared with placebo (four studies) and no medication (one study). In a meta-analysis, we observed no significant differences between topiramate and placebo in improving treatment retention risk ratio (RR) = 0.85; 95% confidence interval (CI) = 0.60-1.22, P = 0.38. However, compared with a placebo, use of topiramate was associated with increased continuous abstinence in two of five studies (RR = 2.43; 95% CI = 1.31-4.53, P = 0.005). No differenc...Continue Reading

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Citations

May 26, 2016·Current Psychiatry Reports·Elias Dakwar, Edward V Nunes
Jul 12, 2016·Addiction·Shane Darke, Michael Farrell
Apr 23, 2019·Current Opinion in Psychiatry·Jonathan Buchholz, Andrew J Saxon
Dec 15, 2018·The American Journal on Addictions·Shannon R KenneyMichael D Stein
Jun 12, 2019·Journal of General Internal Medicine·Brian ChanDevan Kansagara
Jun 20, 2020·PloS One·Claire RonsleyNadia Fairbairn
Dec 9, 2020·Drug and Alcohol Dependence·Craig R RushAbner O Rayapati

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