Topiramate in pregnancy and breastfeeding.

Clinical Drug Investigation
S Gentile

Abstract

Recent information suggests that use of the antiepileptic drug topiramate in pregnancy may raise some concerns, especially if used in polytherapy. Moreover, data on the safety of this antiepileptic drug for the breastfed infant are very limited. However, use of topiramate may be unavoidable in women who wish to become pregnant but who have already experienced severe adverse reactions to antiepileptic medications considered relatively safe in this female condition. Hence, we describe the healthy outcome of a male infant exposed to topiramate through the placenta and maternal milk and who was conceived while the mother was undergoing folic acid supplementation.

References

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Citations

Aug 30, 2013·Italian Journal of Pediatrics·Riccardo DavanzoLorenza Matarazzo
Sep 14, 2014·European Journal of Clinical Pharmacology·Riccardo DavanzoGiulia Facchina
Feb 11, 2015·Epilepsy & Behavior Case Reports·Tone WestergrenBetty Kalikstad
Jun 9, 2014·Seizure : the Journal of the British Epilepsy Association·Arne Reimers
Mar 15, 2012·Fetal and Pediatric Pathology·Seyfettin UludagCihat Sen
Mar 1, 2018·Der Nervenarzt·M CrettenandU Winterfeld
Jun 2, 2012·Expert Review of Neurotherapeutics·Arne Reimers, Eylert Brodtkorb

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