Topiramate, pseudotumor cerebri, weight-loss and glaucoma: an ophthalmologic perspective

Seminars in Ophthalmology
Patrick L AloreMícheál P Macken

Abstract

Approved for the treatment of epilepsy and migraine prophylaxis, topiramate also acts as a carbonic anhydrase inhibitor implying a potential role in the treatment of pseudotumor cerebri (PTC). Topiramate has a propensity to cause anorexia with consequent weight loss, which alone may be curative in PTC. Prescribers must be aware of several reported cases of acute secondary angle-closure glaucoma reported in patients treated with topiramate.

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