Topiramate use during pregnancy and major congenital malformations in multiple populations

Birth Defects Research. Part A, Clinical and Molecular Teratology
Patricia TennisDaina B Esposito

Abstract

We measured birth prevalence of major congenital malformations (MCMs) after topiramate use during pregnancy to screen for a possible signal of increased risk. Using four healthcare databases, we identified three cohorts of pregnant women: cohort 1, used topiramate during the first trimester; cohort 2, used topiramate or another antiepileptic drug previously but not during pregnancy; and cohort 3, were pregnant and did not use topiramate but had indications for use individually matched to those of users. Cohort 1 was compared with cohorts 2 and 3. MCMs were a code for any major congenital malformation dated within 30 days of the delivery date on the mother's claims or within 365 days after infant birth date, excluding a genetic or syndromic basis, and with procedure or healthcare usage consistent with the MCM diagnosis code in the 365 days after infant birth. Of the 10 specific common MCMs evaluated, 1 (conotruncal heart defects) had a prevalence ratio greater than 1.5 for both primary comparisons, and 4 (ventricular septal defect, atrial septal defect, hypospadias, coarctation of the aorta) had a prevalence ratio greater than 1.5 for one of the two comparisons. Following screening of organ systems with elevated MCMs, the preval...Continue Reading

References

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Citations

Dec 22, 2015·Current Psychiatry Reports·Christina L Wichman
Oct 5, 2016·Experimental and Therapeutic Medicine·Qingmei NieJianping Wei
Jun 14, 2019·Neurology·Pierre-Olivier BlotièreRosemary Dray-Spira
Jan 24, 2021·Birth Defects Research·Thabiso TshabalalaFelix Mbajiorgu
Sep 10, 2021·Pharmacoepidemiology and Drug Safety·Andrea V MargulisElena Rivero-Ferrer

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