Topographic and morphometric effects of bilateral embryonic eye removal on the optic tectum and nucleus isthmus of the leopard frog

The Journal of Comparative Neurology
M Constantine-Paton, P Ferrari-Eastman

Abstract

Rana pipiens were raised through metamorphosis after extirpation of both eye primordia at Shumway embryonic stage 17 (Shumway '40). The visual connections between the isthmic nuclei and the optic tectum were examined in these animals using horseradish peroxidase (HRP) histochemistry. Isthmo-tectal projections are normally aligned with the primary retinotectal map. We asked whether these connections would develop normal topographic organization in the absence of normal retinal input. HRP was formed into a solid pellet (congruent to 200-500 micrometer diameter) and inserted into one tectal lobe on the tip of a fine metal probe. The procedure produced relatively restricted retrograde label in somas and dendrites in both isthmi nuclei. In the nucleus isthmus ipsilateral to the tectal lobe receiving the HRP pellet, processes of tecto-isthmi neurons were labeled by anterograde transport. The topography of the isthmo-tectal and tecto-isthmic projections were identical in the developmentally enucleated animals and in normal frogs, even though eye removal severely reduced the volume of the optic tecta and the isthmi nuclei. Thus our analyses indicate that retinal contacts do not play an active role in the development of the positional o...Continue Reading

References

Nov 12, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D J Willshaw, C von der Malsburg
Nov 12, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R A HopeR M Gaze
Apr 26, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J E Cook, T J Horder
Feb 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M M Mesulam
Jun 5, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S H Chung, J Cooke
Feb 2, 1979·Biological cybernetics·C von der Malsburg
Jun 20, 1975·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M C Prestige, D J Willshaw
May 15, 1977·The Journal of Comparative Neurology·W Wilczyniski, R G Northcutt
Jun 1, 1978·The Journal of Comparative Neurology·E R Gruberg, S B Udin
Nov 10, 1978·Science·M Constantine-Paton, M I Law
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M K Heidemann
Apr 2, 1979·Experimental Brain Research·G Rager, B von Oeynhausen
Feb 15, 1979·The Journal of Comparative Neurology·R L Meyer
Feb 1, 1976·The Journal of Experimental Zoology·E M Bloom, R Tompkins
Jan 1, 1976·Brain, Behavior and Evolution·W M Cowan, P G Clarke
Sep 1, 1975·Developmental Biology·J Currie, W M Cowan
Nov 7, 1975·Brain Research·R L Levine, M Jacobson
May 1, 1976·Experimental Neurology·M Hollyday, L Mendell
Jan 1, 1966·Advances in Morphogenesis·G Székely
Oct 1, 1969·The Journal of Comparative Neurology·M Jacobson, R E Baker
Mar 1, 1971·The Journal of Comparative Neurology·V B Eichler
Dec 1, 1971·The Journal of Experimental Zoology·L M Grimm
Apr 18, 1980·Science·A C Rusoff, S S Easter
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M I Law, M Constantine-Paton
Jun 23, 1980·Brain Research·E R Gruberg, J Y Lettvin
Jan 1, 1980·Annual Review of Neuroscience·S E Fraser, R K Hunt
Mar 1, 1954·Proceedings of the Society for Experimental Biology and Medicine·J E DESMEDT
Aug 1, 1956·The Journal of Comparative Neurology·N MINER
Jul 1, 1960·The Journal of General Physiology·H R MATURANAW H PITTS
Oct 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·R W SPERRY

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Citations

Jan 1, 1985·Brain Research·R W RhoadesS E Fish
Aug 27, 1999·Progress in Neurobiology·S B Udin, S Grant
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D D O'Leary, W M Cowan
Oct 1, 1992·The European Journal of Neuroscience·A J Trevelyan, I D Thompson
Dec 15, 1988·The Journal of Comparative Neurology·J J Kollros, M L Thiesse
Aug 10, 1983·The Journal of Comparative Neurology·T A RehM Constantine-Paton
Jan 8, 1987·The Journal of Comparative Neurology·M Constantine-Paton, P Ferrari-Eastman
May 10, 1982·The Journal of Comparative Neurology·J A Stevenson, R D Lund
Feb 20, 1982·The Journal of Comparative Neurology·J J Kollros
Mar 20, 1983·The Journal of Comparative Neurology·G LázárE Kicliter
Dec 20, 1983·The Journal of Comparative Neurology·M R Davis, M Constantine-Paton
Jan 23, 2018·Experimental Eye Research·Cindy X KhaKelly Ai-Sun Tseng
Jan 1, 1985·Journal of Neuroscience Research·T A Reh, M Constantine-Paton

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