Topographic correspondence between white matter hyperintensities and brain atrophy

Journal of Neurology
R RossiG B Frisoni

Abstract

White matter hyperintensities (WMHs) are a common finding in normal elderly persons. We studied the biological damage associated with WMHs by assessing the correspondence between WMH location and regional gray matter loss.Voxel-based morphometry of the gray matter was carried out with statistical parametric mapping on high resolution MR images.Neurologically intact persons with mainly anterior (frontal>parieto-occipital; N = 39) and mainly posterior WMHs (parieto- occipital>frontal; N = 14) were compared with a group devoid of WMHs (N = 80). Subjects with mainly frontal WMHs had bilateral frontal (medial, superior, and inferior gyri) atrophy in gray matter, while subjects with mainly posterior WMHs had more diffuse atrophy, involving mainly the frontal but also the right insular region. Our findings suggest that frontal WMHs are associated with frontal gray matter damage while parietooccipital WMHs seem to have a weaker and more diffuse impact on gray matter.

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Citations

Sep 12, 2009·Clinical Neurology and Neurosurgery·Yangkun ChenWai Kwong Tang
Aug 2, 2008·Journal of the Neurological Sciences·Samantha GalluzziGiovanni B Frisoni
Jul 1, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Aaron McMurtrayVictor Valcour
Apr 7, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Eric JouventHugues Chabriat
Dec 10, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R WangC Qiu
Jan 29, 2014·Journal of the Neurological Sciences·Yunyun XiongVincent Mok
Dec 10, 2016·Hippocampus·Cassidy M FifordUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 21, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Roxane PeresEric Jouvent
Jan 13, 2015·Stroke; a Journal of Cerebral Circulation·Anil M TuladharFrank-Erik de Leeuw
Dec 24, 2015·Stroke; a Journal of Cerebral Circulation·David Alexander DickieJoanna M Wardlaw
Nov 29, 2007·Dementia and Geriatric Cognitive Disorders·Vincent C T MokStephen Wong
Sep 11, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Jun YoshidaKuniaki Ogasawara
Jun 7, 2019·Journal of the American Geriatrics Society·Nienke LegdeurMaría M Corrada
Sep 30, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yifan WangJun Liu

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