Topographic distribution and collateral projections of the two major populations of nigrothalamic neurons. A retrograde labeling study in the rat

Neuroscience Research
Y NishimuraN Mizuno

Abstract

The principal target nuclei of nigrothalamic projections in the rat are the mediodorsal (MD) and ventromedial (VM) nuclei. The present study examined the patterns of distribution and collateral projections of the two major groups of nigrothalamic neurons, i.e., nigro-MD and nigro-VM neurons. Retrograde fluorescent labeling with Fluoro-Gold was used to examine whether the distribution areas of nigro-MD and nigro-VM neurons might be overlapped with or segregated from each other in the substantia nigra pars reticulata. A clear tendency was observed that nigro-MD neurons were distributed more ventrally than nigro-VM neurons. It was further examined by retrograde fluorescent double labeling with Fluoro-Gold and Fluoro-Ruby whether or not these nigrothalamic neurons might provide axon collaterals to the superior colliculus or the pontine reticular formation. The nigro-MD neurons were found to send axon collaterals to the superior colliculus more frequently than the nigro-VM neurons. Additionally, a small number of nigrothalamic neurons were found to send axon collaterals to the pontine reticular formation. The functional significance of the two major populations of nigrothalamic neurons was discussed on the basis of their collateral ...Continue Reading

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Citations

Oct 21, 2003·BMC Medical Research Methodology·David W RobertsonPeter A Singer
Aug 29, 2014·Journal of Integrative Neuroscience·Safiye CavdarOzge Ceren Amuk
May 16, 2002·The Journal of Comparative Neurology·Karl E KroutArthur D Loewy
Oct 12, 2005·The Journal of Comparative Neurology·Carolina CebriánLucía Prensa

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