Topographic distribution of direct and hippocampus- mediated entorhinal cortex activity evoked by olfactory tract stimulation

The European Journal of Neuroscience
V GnatkovskyMarco de Curtis

Abstract

Olfactory information is central for memory-related functions, such as recognition and spatial orientation. To understand the role of olfaction in learning and memory, the distribution and propagation of olfactory tract-driven activity in the parahippocampal region needs to be characterized. We recently demonstrated that repetitive stimulation of the olfactory tract in the isolated guinea pig brain preparation induces an early direct activation of the rostrolateral entorhinal region followed by a delayed response in the medial entorhinal cortex (EC), preceded by the interposed activation of the hippocampus. In the present study we performed a detailed topographic analysis of both the early and the delayed entorhinal responses induced by patterned stimulation of the lateral olfactory tract in the isolated guinea pig brain. Bi-dimensional maps of EC activity recorded at 128 recording sites with 4 x 4 matrix electrodes (410 microm interlead separation) sequentially placed in eight different positions, showed (i) an early (onset at 16.09 +/- 1.2 ms) low amplitude potential mediated by the monosynaptic LOT input, followed by (ii) an associative potential in the rostral EC which originates from the piriform cortex (onset at 33.2 +/- ...Continue Reading

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Citations

Aug 16, 2011·Cerebral Cortex·Gunes UnalDenis Paré
Apr 7, 2015·Journal of Neuroscience Methods·Marco de CurtisLaura Uva
Oct 21, 2015·Frontiers in Neuroscience·Barbara FerryMonique Majchrzak
Aug 7, 2007·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Etienne LabytFabrice Wendling
Aug 26, 2014·Frontiers in Systems Neuroscience·Panagiotis C Petrantonakis, Panayiota Poirazi
Jul 28, 2016·Behavioural Brain Research·Thomaz Lüscher DiasGrace Schenatto Pereira
Jun 24, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Zhi-Gang YaoYe-Jun Qin

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