Topographic distribution of seizure onset and hippocampal atrophy: relationship between MRI and depth EEG

Electroencephalography and Clinical Neurophysiology
D KingS S Spencer

Abstract

Medial temporal lobe epilepsy (MTLE) is associated with hippocampal cell loss and organization of the dentate gyrus. Some studies suggest a correlation between the topographic distribution of cell loss and site of epileptogenesis. We studied the relationship between the site of ictal onset with the presence of segmental atrophy in patients with non-lesional MTLE using magnetic resonance imaging (MRI) and depth EEG. Ictal recordings were obtained from 27 patients with longitudinal hippocampal depth electrodes and variable combinations of subdural strips sampling medial temporal structures. The location of the depth electrode contacts was correlated with anatomical landmarks. Seizures were analyzed for the distribution of onset along the long axis of the hippocampus. MRI analysis were performed to detect segmental atrophy. Outcome was assessed 1 year or more following anterior temporal lobectomy. Twenty-five patients had unilateral, and two had bilateral, hippocampal atrophy. One hundred and forty-seven seizures were reviewed: 21 showed focal onset and 126 showed regional onset. Ictal onset involved the amygdala and anterior half of the hippocampus in 80% of the seizures while only 40% of patients had atrophy of these segments. M...Continue Reading

References

Aug 1, 1992·Brain : a Journal of Neurology·M J CookJ M Stevens
Jan 1, 1991·Magnetic Resonance Imaging·R A Bronen, G Cheung
Dec 30, 1985·Brain Research·M GilbertG K Smith

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Citations

Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·S P C BowerM J Cook
Oct 23, 2010·Journal of Cognitive Neuroscience·Andrea B Protzner, Mary Pat McAndrews
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Izumi ToyodaPaul S Buckmaster
Jun 25, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nealen G LaxpatiRobert E Gross
May 5, 2009·Epilepsy Research·Shalini MukherjeeK K Deepak
May 18, 2004·Epilepsia·Heinz-Gregor Wieser, UNKNOWN ILAE Commission on Neurosurgery of Epilepsy
May 14, 2009·Hippocampus·Sandhitsu R DasPaul A Yushkevich
Jan 11, 2011·Epilepsy & Behavior : E&B·Gulce Unal YildizNurhan Ilhan
Oct 13, 2014·Epilepsy Research·Pue Farooque, Robert Duckrow
Apr 29, 2005·Brain : a Journal of Neurology·Stéphan ChabardèsAlim Louis Benabid
Aug 15, 2019·Epilepsy Currents·David King-Stephens
Jun 29, 2017·Brain Structure & Function·Alejandra Magagna-PovedaHelen E Scharfman

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