Topographic evaluation of relatives of patients with keratoconus

Cornea
Farid KarimianNasrin Rafati

Abstract

To evaluate topographic corneal changes in relatives of patients with keratoconus (KCN). In a prospective study, 300 eyes of 150 relatives of 45 patients with KCN were evaluated. Complete slit-lamp examination, refraction, and corneal topography were performed for all eyes. The topographic indices for diagnosis of KCN were from Rabinowitz criteria. The study included 84 (56%) female and 66 (44%) male subjects. Mean age was 32.4 +/- 15 years (range, 16-83 years). KCN was diagnosed in 14% of the subjects and another 7.3% were suspicious for KCN. The overall prevalence of astigmatism was 58%, including 42.1% in the KCN group, 66.7% in the KCN suspect group, and 49.6% in the healthy group. Thirty-one eyes had high regular astigmatism (>1.5 D) including 17 (54.8%) in the KCN group and 14 (45.2%) in the healthy group. Oblique astigmatism was seen in 33 (11%) eyes, including 34.2% in the KCN group, 47.6% in the suspicious KCN group, and 4.6% in the healthy group. Relatives of patients with KCN have a high prevalence of undiagnosed KCN. Corneal topography is important for the diagnosis of KCN and KCN suspects in family members of patients with KCN. Therefore, keratorefractive surgery should be considered cautiously in these individuals.

Associated Clinical Trials

References

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Citations

Mar 10, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jose Luis MatoElío Díez-Feijoo
Feb 9, 2012·Cornea·Yee Onn KokSeng Chee Loon
Apr 16, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Ariela Gordon-ShaagEinat Shneor
Feb 1, 2012·Journal of Ophthalmology·Yelda OzkurtSezen Akkaya
May 17, 2011·Middle East African Journal of Ophthalmology·Dorota M Nowak, Marzena Gajecka
Aug 20, 2015·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Ariela Gordon-ShaagEinat Shneor
Aug 13, 2013·American Journal of Ophthalmology·Engin Bilge OzgurhanAhmet Demirok
Sep 18, 2012·Journal français d'ophtalmologie·S Léoni-MespliéJ Colin
Jun 27, 2015·Cornea·Charles N J McGheePeter J Wilson
Sep 18, 2015·BioMed Research International·Khaled K Abu-AmeroYutao Liu
Dec 17, 2014·Eye & Contact Lens·Mohammad NaderanRozhin Pahlevani
Jun 5, 2015·Journal of Negative Results in Biomedicine·Khaled K Abu-AmeroYutao Liu
Jun 16, 2015·BioMed Research International·Ariela Gordon-ShaagYutao Liu
Feb 25, 2015·Oman Journal of Ophthalmology·Mahgol FarjadniaMehrdad Mohammadpour
Jun 29, 2016·Eye and Vision·Yelena BykhovskayaYaron S Rabinowitz
Jan 10, 2017·Journal of Refractive Surgery·Georgios D KymionisMiltiadis K Tsilimbaris
Mar 25, 2018·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Hassan HashemiMehdi Khabazkhoob
Mar 3, 2017·BioMed Research International·Mariam Lotfy KhaledYutao Liu
Nov 8, 2017·Ophthalmic Genetics·Hanne ValgaerenGuy Van Camp
Jul 25, 2020·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Einat ShneorAriela Gordon-Shaag
Jun 8, 2017·International Ophthalmology Clinics·Katherine J Davis, Shahzad I Mian
Jul 6, 2017·Scientific Reports·Shi Song RongLi Jia Chen
Sep 25, 2020·Cornea·Gabrielle LapeyreDavid Touboul
Jun 18, 2021·Frontiers in Cell and Developmental Biology·Shihao ChenZi-Bing Jin

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