PMID: 7545858Jan 1, 1995Paper

Topographic involvement of the striatal efferents in basal ganglia of patients with adult-onset motor neuron disease with basophilic inclusions

Acta Neuropathologica
H ItoT Imai

Abstract

This report concerns the topographic immunohistochemical analysis of the putamen, globus pallidus (GP) and substantia nigra (SN) of two patients with adult-onset motor neuron disease with basophilic inclusions (MND/BIs), seven patients with sporadic classic amyotrophic lateral sclerosis (sporadic ALS) and five neurologically normal individuals. The striatal efferent terminals of the GP and SN were visualized immunohistochemically using antibodies to met-enkephalin (MEnk) and substance P (SP). In specimens from patients with sporadic ALS and normal subjects there was intense immunostaining for MEnk and SP throughout the external and internal segments of the GP, respectively. By contrast, a marked reduction of MEnk- and SP-positive striatal efferents was seen in the ventrocaudal portions of both GP segments from the MND/BIs patients. Moreover, while MEnk-positive striosomes was readily detected in the putamen of normals and sporadic ALS patients, there was significant reduction in MEnk immunoreactivity, and no evidence of striosomal organization in the putamen of MND/BIs patients. In addition, whereas the SN of patients with sporadic ALS expressed SP, the ventrolateral SN portion of the MND/BIs patient tested had reduced immunore...Continue Reading

References

Oct 1, 1992·Annals of Neurology·H ItoA Hirano
Jan 1, 1992·Acta Neuropathologica·S SasakiS Maruyama
Jan 1, 1989·Acta Neuropathologica·S GotoR R Rojas-Corona
Oct 1, 1989·Journal of the Neurological Sciences·H Hayashi, S Kato
Nov 11, 1988·Neuroscience Letters·P N LeighD M Power
Jan 1, 1985·Acta Neuropathologica·F GrayJ Poirier
Sep 1, 1973·Neurology·K BraitG A Schwarz
Jun 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·B BrownellJ T Hughes
Aug 1, 1968·Medical & Biological Engineering·B W Watson, J S Fleming
Feb 1, 1969·Journal of Neurology, Neurosurgery, and Psychiatry·J G Graham, D R Oppenheimer
Sep 1, 1984·Annals of Neurology·D S HoroupianJ Blass
Jan 1, 1984·Acta Neuropathologica·J TanakaK Takahashi
Sep 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·Y Mitsuyama
Aug 1, 1993·Neuropathology and Applied Neurobiology·S KatoH Tanabe
Jan 1, 1955·Confinia Neurologica·A BIEMOND, W BECK

❮ Previous
Next ❯

Citations

Jul 9, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Claire O'CallaghanMichael Hornberger
Sep 18, 2012·Journal of the Neurological Sciences·Yoko MochizukiToshio Mizutani
Sep 25, 2002·The Journal of Comparative Neurology·Rosalinda C Roberts, Joy K Knickman
Sep 14, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Liliana Olim Gouveia, Mamede de Carvalho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.