Topographic organization of the basal forebrain projections to the perirhinal, postrhinal, and entorhinal cortex in rats

The Journal of Comparative Neurology
Hideki Kondo, L Zaborszky

Abstract

Previous studies have shown that the basal forebrain (BF) modulates cortical activation via its projections to the entire cortical mantle. However, the organization of these projections is only partially understood or, for certain areas, unknown. In this study, we examined the topographic organization of cholinergic and noncholinergic projections from the BF to the perirhinal, postrhinal, and entorhinal cortex by using retrograde tracing combined with choline acetyltransferase (ChAT) immunohistochemistry in rats. The perirhinal and postrhinal cortex receives major cholinergic and noncholinergic input from the caudal BF, including the caudal globus pallidus and substantia innominata and moderate input from the horizontal limb of the diagonal band, whereas the entorhinal cortex receives major input from the rostral BF, including the medial septum and the vertical and horizontal limbs of the diagonal band. In the perirhinal cases, cholinergic projection neurons are distributed more caudally in the caudal globus pallidus than noncholinergic projection neurons. Compared with the perirhinal cases, the distribution of cholinergic and noncholinergic neurons projecting to the postrhinal cortex shifts slightly caudally in the caudal glob...Continue Reading

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Citations

Jul 19, 2016·Neuron·James R HinmanMichael E Hasselmo
Sep 1, 2016·CNS Neuroscience & Therapeutics·Chun-Ni GuoJun Lu
Dec 26, 2017·Frontiers in Neural Circuits·Joshua ObermayerHuibert D Mansvelder
Jul 29, 2018·The European Journal of Neuroscience·Nicola Solari, Balázs Hangya
Jun 26, 2020·Annual Review of Vision Science·Aaron D Garcia, Elizabeth A Buffalo
Jul 5, 2018·Cell Reports·Taylor W SchmitzUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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