Topographic Reconfiguration of Local and Shared Information in Anesthetic-Induced Unconsciousness

Entropy
Heonsoo LeeAnthony G Hudetz

Abstract

Theoretical consideration predicts that the alteration of local and shared information in the brain is a key element in the mechanism of anesthetic-induced unconsciousness. Ordinal pattern analysis, such as permutation entropy (PE) and symbolic mutual information (SMI), have been successful in quantifying local and shared information in neurophysiological data; however, they have been rarely applied to altered states of consciousness, especially to data obtained with functional magnetic resonance imaging (fMRI). PE and SMI analysis, together with the superb spatial resolution of fMRI recording, enables us to explore the local information of specific brain areas, the shared information between the areas, and the relationship between the two. Given the spatially divergent action of anesthetics on regional brain activity, we hypothesized that anesthesia would differentially influence entropy (PE) and shared information (SMI) across various brain areas, which may represent fundamental, mechanistic indicators of loss of consciousness. FMRI data were collected from 15 healthy participants during four states: wakefulness (W), light (conscious) sedation (L), deep (unconscious) sedation (D), and recovery (R). Sedation was produced by th...Continue Reading

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