Topographical distribution of microscopic colitis and the importance of orientation of paraffin-embedded biopsies.

Human Pathology
Anne-Marie Kanstrup FiehnVincenzo Villanacci

Abstract

The diagnosis of microscopic colitis (MC) relies on specific histopathological findings in colon biopsies. The number of biopsies needed to diagnose MC remains disputed. The aim of the study was to determine the number and site of biopsies necessary for the diagnosis and the effect of perpendicular orientation when embedding the biopsies. This retrospective multicenter European study included 42 patients with a consensus diagnosis of collagenous colitis (CC), 51 patients with lymphocytic colitis (LC), and three patients with incomplete LC (LCi). The number of individual diagnostic biopsies from each patient was determined. The diagnostic rate of 744 individual biopsies from 96 patients with MC was 69.5% for the specific MC subgroup, 79.4% for MC and 93.4% for MC plus incomplete MC (MCi). The risk of missing a diagnosis of the specific subgroup of MC when analyzing four biopsies was 0.87%, decreasing to 0.18% for MC and 0.0019% for MC plus MCi. More biopsies from the right colon were diagnostic of the specific MC subgroup (76.3% vs. 64.0%, p = 0.0014). Perpendicular orientation of biopsies increased the diagnostic rate of the specific MC subgroup (73.1% vs. 65.0%, p = 0.0201). Histological changes diagnostic of MC were present i...Continue Reading

References

Sep 1, 1992·Journal of Clinical Pathology·J ArmesP S Bhathal
Jul 1, 1987·Digestive Diseases and Sciences·A PriorP J Whorwell
Jun 1, 1995·Gut·B VeressL Bergman
May 1, 1995·Mayo Clinic Proceedings·B J ZinsH A Carpenter
Feb 18, 1999·The American Journal of Gastroenterology·F Fernández-BañaresJ M Viver
Apr 12, 2000·The American Journal of Medicine·C A MatteoniE E Soffer
May 23, 2002·Digestive Diseases and Sciences·Margret AgnarsdottirJon Gunnlaugur Jonasson
Jul 31, 2008·World Journal of Gastroenterology : WJG·Levent ErdemOnder Peker
Oct 5, 2011·Alimentary Pharmacology & Therapeutics·C BjørnbakL K Munck
Jan 25, 2012·Digestion·Ken NarabayashiKazuhide Higuchi
Jul 9, 2014·The American Journal of Gastroenterology·Gilles MacaigneStéphane Nahon
Nov 11, 2014·Histopathology·Cord LangnerUNKNOWN Working Group of Digestive Diseases of the European Society of Pathology (ESP) and the European Microscopic Colitis Group (E
Dec 7, 2014·Gastrointestinal Endoscopy·Douglas K RexDavid S Weinberg
Jun 27, 2015·European Journal of Gastroenterology & Hepatology·Robert M Genta, Amnon Sonnenberg
Nov 2, 2015·Journal of Crohn's & Colitis·Julie RasmussenLars Kristian Munck
Nov 26, 2015·Alimentary Pharmacology & Therapeutics·F Fernández-BañaresUNKNOWN Spanish Microscopic Colitis Group (SMCG)
Feb 22, 2017·Clinics and Research in Hepatology and Gastroenterology·Gilles MacaigneUNKNOWN COLMI Group of the Association Nationale des Gastroentérologues des Hôpitaux (ANGH)
Mar 13, 2019·The Lancet. Gastroenterology & Hepatology·Stephan MiehlkeAndreas Münch
Feb 29, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Boris VirineDavid K Driman
Apr 12, 2020·Annals of Diagnostic Pathology·Danny GoudkadePeter Johan Heiberg Engel

❮ Previous
Next ❯

Citations

Sep 14, 2020·International Journal of Colorectal Disease·Anne-Marie Kanstrup FiehnAndreas Münch
Mar 14, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luca Reggiani BonettiVincenzo Villanacci
Jun 12, 2021·Nature Reviews. Disease Primers·Kristin E BurkeHamed Khalili
Aug 21, 2021·United European Gastroenterology Journal·Andreas MünchLars Kristian Munck

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Boris VirineDavid K Driman
Journal of Crohn's & Colitis
Julie RasmussenLars Kristian Munck
International Journal of Colorectal Disease
Anne-Marie Kanstrup FiehnA Münch
© 2021 Meta ULC. All rights reserved