Topographical organization of opioid peptide precursor gene expression following repeated apomorphine treatment in the 6-hydroxydopamine-lesioned rat

Experimental Neurology
S DutyJonathan M Brotchie

Abstract

Many studies have previously described changes in preproenkephalin-A (PPE-A) and preproenkephalin-B (PPE-B) gene expression in the striatum of the 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease (both with or without dopamine replacement treatment). To date, these studies have either taken the striatum as a whole or have focused on a single subregion of the striatum. However, the striatum is organized into anatomically discrete parallel circuits serving different functions (motor, associative, and limbic). We have therefore employed in situ hybridization to examine the detailed topography of changes in opioid precursor expression following dopamine depletion and subsequent treatment with apomorphine (5 mg/kg twice daily for 10 days). In the untreated 6-OHDA-lesioned striatum PPE-A expression was elevated only in the dorsal (sensorimotor) caudate-putamen. Following apomorphine treatment PPE-A mRNA levels were further raised in the sensorimotor striatum (</=77%) and approximately doubled and tripled in the ventral caudate-putamen (associative) and nucleus accumbens (limbic), respectively. These subsequent elevations were mostly restricted to rostral portions of the striatum. Although unchanged following vehic...Continue Reading

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Citations

Oct 14, 2003·Experimental Neurology·Brian HenryJonathan M Brotchie
Jul 12, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Jonathan M Brotchie
Feb 11, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J E NashJ M Brotchie
Feb 21, 2002·Journal of Neuropathology and Experimental Neurology·Frédéric CalonThérèse Di Paolo
Feb 23, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Susan H FoxJonathan M Brotchie
Feb 13, 2001·Experimental Neurology·M B HarrisonJ M Trugman

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