Topography and functional role of dopaminergic projections from the ventral mesencephalic tegmentum to the ventral pallidum

M A KlitenickP W Kalivas


A dopaminergic projection from the ventral tegmental area to the ventral pallidum was identified in the rat using anterograde tract tracing and combined retrograde tracing-immunocytochemistry. The projection was found to be topographically organized such that fibers innervating the ventromedial ventral pallidum arose from neurons located along the midline nuclei of the ventral mesencephalon, including the nucleus interfascicularis and nucleus linearis caudalis. Ventral tegmental neurons situated more laterally, in the nucleus parabrachialis pigmentosus and nucleus paranigralis, projected to the ventromedial and dorsolateral ventral pallidum. The substantia nigra did not supply a major contribution to this projection. The proportion of ventral tegmental area dopaminergic neurons projecting to the ventral pallidum ranged from approximately 30% to 60%. The functional significance of the projection is indicated since intra-ventral pallidum microinjections of dopamine elicited a dose-dependent increase in locomotor activity. Furthermore, whereas pretreatment of the ventral pallidum with the GABAA agonist muscimol has been shown to attenuate opioid-induced locomotor activity elicited from the ventral pallidum, it did not attenuate th...Continue Reading


Aug 31, 2012·Brain Structure & Function·Anushree TripathiElisa Mengual
Sep 1, 1995·Brain Research. Brain Research Reviews·W R van FurthJ M Van Ree
Jun 1, 1995·Behavioural Brain Research·G PanagisC Spyraki
Mar 1, 1994·Brain Research. Molecular Brain Research·C CerrutiM J Kuhar
May 5, 2005·Experimental Neurology·Thomas DebeirRita Raisman-Vozari
May 1, 1997·Pharmacology, Biochemistry, and Behavior·M A KrausC Kornetsky
Dec 24, 1997·Brain Research. Brain Research Reviews·R C Pierce, P W Kalivas
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Dec 19, 1998·Journal of the Autonomic Nervous System·M IwaseI Homma
Jan 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·A GasbarriM G Packard
Feb 7, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Y AnagnostakisC Spyraki
Oct 29, 2000·Trends in Neurosciences·Y Smith, J Z Kieval
Sep 29, 2004·Nature Neuroscience·Larry J Young, Zuoxin Wang
Aug 1, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amanda L MickiewiczT C Napier
Oct 9, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S N Haber, Brian Knutson
Aug 14, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susan R Sesack, Anthony A Grace
Feb 3, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stanislav KoulchitskyVincent Seutin


Aug 15, 1975·The Journal of Comparative Neurology·T HattoriP L McGeer
Jul 10, 1978·Cell and Tissue Research·O Lindvall, U Stenevi
Jul 11, 1975·Brain Research·L W Swanson, W M Cwan
Jul 23, 1991·European Journal of Pharmacology·R J Maslowski, T C Napier
Nov 15, 1988·The Journal of Comparative Neurology·E A Grove
Jan 1, 1988·Annals of the New York Academy of Sciences·A Y DeutchR H Roth
Jul 1, 1986·Pharmacology, Biochemistry, and Behavior·N R SwerdlowG F Koob
Apr 15, 1987·The Journal of Comparative Neurology·T A FullerJ L Price
Jan 22, 1987·The Journal of Comparative Neurology·D S ZahmL Heimer
Mar 1, 1988·Neuroscience·R P Vertes
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Dec 1, 1985·The Journal of Comparative Neurology·F T RusschenJ L Price
May 15, 1985·The Journal of Comparative Neurology·S N HaberW J Nauta
Jan 1, 1972·The Journal of Comparative Neurology·M B Carpenter, P Peter

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