PMID: 21609311May 26, 2011Paper

Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
Dharmendra Kumar MauryaMasaaki Tamura

Abstract

The effect of SN-38 was evaluated on multiple lung cancer cell lines. It inhibits anchorage-dependent and -independent growth as monitored by MTT and soft agar colony assay, respectively. SN-38 collapsed the mitochondrial membrane potential (MMP), arrested cells in S- and G2-phases of the cell cycle, and induced apoptosis via activation of caspase 3 and PARP. A single injection of 2 mg/kg body weight of SN-38 caused a significant reduction of lung cancer xenografts. These findings indicate that SN-38 induces apoptosis in the lung cancer cells effectively. Thus, SN-38 can potentially be an effective therapeutic agent against lung cancer.

References

Aug 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N MasudaM Takada
Nov 12, 1992·The New England Journal of Medicine·D C Ihde
Nov 1, 1991·Cancer·O Auerbach, L Garfinkel
Apr 29, 1998·Annual Review of Physiology·Guido KroemerM Resche-Rigon
Jan 6, 1999·Biophysical Journal·R C Scaduto, L W Grotyohann
Feb 26, 2000·Carcinogenesis·S W Lowe, A W Lin
Oct 26, 2000·Nature·M O Hengartner
Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J B CustódioL M Almeida
Oct 25, 2001·Blood·I Herr, Klaus-Michael Debatin
Jan 11, 2002·The New England Journal of Medicine·Kazumasa NodaJapan Clinical Oncology Group
Sep 17, 2002·Cell Death and Differentiation·G van LooP Vandenabeele
Dec 17, 2002·Oncogene·Klaus-Michael DebatinGuido Kroemer
Jul 23, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kimihiko OhtsukaAkira Shida
Oct 8, 2003·Current Medicinal Chemistry·Yoh DobashiAkishi Ooi
May 15, 2004·Cancer Letters·G Radhakrishna PillaiEwa Carrier
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas J LynchCarol S Hart
Apr 2, 2005·Neoplasia : an International Journal for Oncology Research·Simone Fulda, Klaus-Michael Debatin
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis