PMID: 11325482Apr 28, 2001Paper

Topoisomerase IIalpha and other drug resistance markers in advanced non-small cell lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
A M DingemansG Giaccone

Abstract

Resistance to chemotherapy is common in non-small cell lung cancer. The aim of this study was to investigate the prognostic impact of in vitro established drug resistance markers on the response to chemotherapy in patients with advanced non-small cell lung cancer. Samples of 38 patients were analyzed by immunohistochemical staining, for topoisomerase IIalpha and IIbeta, Ki-67, MRP and LRP. In addition, mutation analysis of the topoisomerase IIalpha gene, the B/DNBS and the Tyr804 region, was performed. Lung tumor biopsies were taken prior for treatment with one of the following regimens; cisplatin/paclitaxel, cisplatin/VM26 or VP16, or carboplatin/VP16/ifosfamide. Seventeen patients obtained a partial response, 12 had stable disease and nine patients had progressive disease. None of the investigated markers was related with overall response rate. In one sample a point mutation in the B/DNBS region of the topo IIalpha gene was detected which substitutes IIe(510) with Val. This tumor had a partial response to four courses of cisplatin/VP16 treatment. The survival analysis showed that the patients with high topo IIalpha expressing tumors had a significantly worse survival compared with the patients with low or intermediate topo II...Continue Reading

References

Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B Y BuggD P Suttle
Aug 2, 1989·Journal of the National Cancer Institute·S L LaiA F Gazdar
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M Tsai-PflugfelderJ C Wang
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·G J ZamanH J Broxterman
Dec 27, 1995·Biochimica Et Biophysica Acta·G GiacconeJ Walboomers
Jan 17, 1996·International Journal of Cancer. Journal International Du Cancer·M A IzquierdoR J Scheper
Jun 11, 1996·International Journal of Cancer. Journal International Du Cancer·G GiacconeH M Pinedo
Aug 30, 1996·The Journal of Biological Chemistry·K KimuraA Kikuchi
Sep 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Y S VassetzkyS M Gasser
Aug 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A M DingemansG Giaccone
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·W BergerM Micksche
Sep 28, 1998·Biochimica Et Biophysica Acta·A M DingemansG Giaccone
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M KawasakiN Hara

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Citations

Mar 10, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Areeg FaggadCarsten Denkert
Feb 9, 2008·Pharmacology·Howard R Mellor, Richard Callaghan
Sep 2, 2011·European Journal of Clinical Investigation·Zhenwen ChenGuoping Wang
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ikuo SekineNagahiro Saijo
May 11, 2005·Biochemical and Biophysical Research Communications·Masashi OdaJun A Takahashi
Feb 23, 2012·Cancer Biology & Therapy·Weihong ZhaoQimin Zhan
Nov 10, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jan Nyrop Jakobsen, Jens Benn Sørensen
Jul 20, 2004·Molecular Pharmacology·Krzysztof LemkeAnnette K Larsen
Mar 5, 2003·Pharmacological Reviews·Romano DanesiMario Del Tacca
Dec 24, 2019·Frontiers in Genetics·Beatriz Andrea Otálora-OtáloraAdriana Rojas
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin FilipitsRobert Pirker
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kiyotaka YohAtsushi Ochiai
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Adil DaudDaniel Sullivan
Jun 7, 2006·Cirugía española·Alfredo ParedesMiguel Echenique-Elizondo

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