PMID: 9169823Mar 15, 1997Paper

Topoisomerase inhibition by lucanthone, an adjuvant in radiation therapy

International Journal of Radiation Oncology, Biology, Physics
R E Bases, F Mendez

Abstract

To determine whether lucanthone can inhibit human topoisomerases in vitro. Lucanthone was incubated with human topoisomerases II and I together with their plasmid substrates, to determine if lucanthone interfered with the catalytic activities of topoisomerases and if it enhanced the formation of DNA strand breaks, as determined by agarose gel electrophoresis of the resultant plasmid forms. Incubation of the enzymes with lucanthone inhibited the catalytic activity of topoisomerases II and I. With topoisomerase II, it increased the abundance of DNA double strand breaks (cleavable complexes). Lucanthone, like actinomycin D, inhibited topoisomerases II and I. It may act to enhance the yield of DNA double strand breaks in cells through a mechanism of topoisomerase II inhibition.

References

Mar 1, 1978·International Journal of Radiation Oncology, Biology, Physics·R Bases
Nov 1, 1978·International Journal of Radiation Oncology, Biology, Physics·M P Nobler, A J Scher
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G Capranico, F Zunino
Jan 1, 1989·Annual Review of Biochemistry·L F Liu
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H ZhangL F Liu
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Mar 1, 1981·International Journal of Radiation Oncology, Biology, Physics·J PadawerE Seifter

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Citations

Sep 3, 2010·Cellular and Molecular Life Sciences : CMLS·David M Wilson, Anton Simeonov
Sep 16, 1999·Biochemical Pharmacology·L Dassonneville, C Bailly
Feb 16, 1999·International Journal of Radiation Oncology, Biology, Physics·J D Del RoweR Bases
Aug 22, 2008·Antioxidants & Redox Signaling·Aditi BapatMark R Kelley
Nov 29, 2007·Molecular Pharmacology·Lauren A SeipleJames T Stivers
Jan 9, 2010·Cancer Treatment Reviews·Rachel Abbotts, Srinivasan Madhusudan
Nov 27, 2002·Cancer Investigation·Frances MendezRobert E Bases
Jun 15, 2007·Molecular Aspects of Medicine·Melissa L Fishel, Mark R Kelley
Mar 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana LopesCarla Fernandes

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