PMID: 9449288Feb 4, 1998Paper

Topoisomerase mutations in fluoroquinolone-resistant and methicillin-susceptible and -resistant clinical isolates of Staphylococcus aureus

Antimicrobial Agents and Chemotherapy
G W Kaatz, S M Seo

Abstract

The incidence of the various mutations in the genes encoding topoisomerase IV and DNA gyrase in fluoroquinolone-resistant clinical isolates of Staphylococcus aureus is not known. Using restriction fragment length polymorphism analysis and DNA sequencing, we found that in fluoroquinolone- and methicillin-resistant strains, mutations in grlA and gyrA are quite likely to be present together. For fluoroquinolone-resistant but methicillin-susceptible strains, mutations in grlA alone are more common.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Mar 1, 1992·Journal of Clinical Microbiology·R V Goering, M A Winters
May 1, 1993·Antimicrobial Agents and Chemotherapy·G W KaatzC A Ruble

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Citations

Oct 20, 2001·Pharmacotherapy·D T Bearden, L H Danziger
Jan 6, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·B ShopsinB N Kreiswirth
Oct 31, 1998·Antimicrobial Agents and Chemotherapy·M TanakaK Sato
Jan 26, 2002·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·M TanakaK Sato

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