Topological Disruption of Structural Brain Networks in Patients With Cognitive Impairment Following Cerebellar Infarction

Frontiers in Neurology
Duohao WangJingping Shi

Abstract

Cerebellar lesions can lead to a series of cognitive and emotional disorders by influencing cerebral activity via cerebro-cerebellar loops. To explore changes in cognitive function and structural brain networks in patients with posterior cerebellar infarction, we conducted the current study using diffusion-weighted MRI (32 cerebellar infarction patients, 29 controls). Moreover, a series of neuropsychological tests were used to assess the subject's cognitive performance. We found cognitive impairment following cerebellar infarction involving multiple cognitive domains, including memory, executive functions, visuospatial abilities, processing speed and language functions, and brain topological abnormalities, including changes in clustering coefficients, shortest path lengths, global efficiency, local efficiencies, betweenness centrality and nodal efficiencies. Our results indicated that measures of local efficiency, mainly in the precuneus, cingulate gyrus and frontal-temporal cortex, were significantly reduced with posterior cerebellar infarction. At the same time, The correlation analysis suggested thatthe abnormal alterations in the right PCG, bilateral DCG, right PCUN may play a core role in the cognitive impairment following...Continue Reading

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Citations

Feb 10, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Hyung-Ji KimJae-Hong Lee
Jun 10, 2021·Interdisciplinary Sciences, Computational Life Sciences·Xia-An BiZhaoxu Xing

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