Topological FDR for neuroimaging.

NeuroImage
J ChumbleyK Friston

Abstract

In this technical note, we describe and validate a topological false discovery rate (FDR) procedure for statistical parametric mapping. This procedure is designed to deal with signal that is continuous and has, in principle, unbounded spatial support. We therefore infer on topological features of the signal, such as the existence of local maxima or peaks above some threshold. Using results from random field theory, we assign a p-value to each maximum in an SPM and identify an adaptive threshold that controls false discovery rate, using the Benjamini and Hochberg (BH) procedure (1995). This provides a natural complement to conventional family wise error (FWE) control on local maxima. We use simulations to contrast these procedures; both in terms of their relative number of discoveries and their spatial accuracy (via the distribution of the Euclidian distance between true and discovered activations). We also assessed two other procedures: cluster-wise and voxel-wise FDR procedures. Our results suggest that (a) FDR control of maxima or peaks is more sensitive than FWE control of peaks with minimal cost in terms of false-positives, (b) voxel-wise FDR is substantially less accurate than topological FWE or FDR control. Finally, we pr...Continue Reading

References

Nov 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J WorsleyP Neelin
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K M PeterssonA P Holmes
Sep 6, 2006·NeuroImage·Ruth HellerYoav Benjamini
Jan 1, 1994·Human Brain Mapping·K J FristonA C Evans

❮ Previous
Next ❯

Citations

May 19, 2010·Neuroradiology·Hidemasa TakaoKuni Ohtomo
Feb 27, 2013·Neuroradiology·Yasuyuki TakiHiroshi Fukuda
Sep 9, 2011·Brain Imaging and Behavior·Shanker SwaminathanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 13, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eugenia RadulescuStefano Marenco
Mar 10, 2012·Social Cognitive and Affective Neuroscience·Nicole Van HoeckFrank Van Overwalle
Feb 29, 2008·The American Journal of Chinese Medicine·Tsung-Jung HoJaung-Geng Lin
Jan 9, 2008·Journal of Integrative Neuroscience·Fredrik EdinJesper Tegnér
Jan 8, 2011·Journal of Integrative Neuroscience·M J RosaK J Friston
Jan 8, 2011·Journal of Integrative Neuroscience·Tianxiang ZhengTianzi Jiang
Dec 15, 2010·Journal of Neurophysiology·Giovanni GentileH Henrik Ehrsson
Mar 7, 2012·Journal of Cognitive Neuroscience·Francesca CarotaFriedemann Pulvermüller
Nov 10, 2013·PloS One·Martin GöttlichUlrike M Krämer
Jul 25, 2014·PloS One·Joanna A ChristodoulouJohn D E Gabrieli
May 21, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caroline F ZinkAndreas Meyer-Lindenberg
Jan 21, 2014·Epilepsy Research·Ke PengPhilippe Pouliot
Jan 8, 2014·Journal of Cognitive Neuroscience·Malia MasonSusan T Fiske
Aug 26, 2014·Experimental Brain Research·Laura ZapparoliEraldo Paulesu
Jul 23, 2013·Cognitive, Affective & Behavioral Neuroscience·Joke DurnezThomas E Nichols
Feb 18, 2016·Journal of Neuroscience Methods·Ruiyang GeZhiying Long
Oct 21, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ben M HarveySerge O Dumoulin
Feb 7, 2016·Cerebral Cortex·Mathieu d'Acremont, Peter Bossaerts
Nov 27, 2015·NeuroImage·Francesco Di RussoGaspare Galati
Nov 14, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Do-Hyung KangJun Soo Kwon
Feb 7, 2012·Neuroscience and Biobehavioral Reviews·Hanneke van EwijkJaap Oosterlaan
Jan 5, 2016·International Journal of Medical Informatics·Cyril R PernetJoanna Wardlaw
Dec 8, 2015·Journal of Affective Disorders·Wenjing YangJiang Qiu
Mar 11, 2011·Human Brain Mapping·Marie-Hélène GrosbrasSimon B Eickhoff
Oct 22, 2010·Human Brain Mapping·César Caballero GaudesPenny A Gowland
Apr 6, 2016·Frontiers in Human Neuroscience·Michael D MrazekJonathan W Schooler
Jul 25, 2013·Human Brain Mapping·Giancarlo ValenteElia Formisano
May 9, 2014·Biometrical Journal. Biometrische Zeitschrift·Joke DurnezBeatrijs Moerkerke
Jan 31, 2012·IEEE Transactions on Medical Imaging·Yimei LiHongtu Zhu
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Brian S MohlenhoffThomas C Neylan
Aug 7, 2014·Brain Structure & Function·Annalisa TosoniGaspare Galati

❮ Previous
Next ❯

Software Mentioned

SPM8
SurfStat

Related Concepts

Related Feeds

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
K WorsleyP Neelin
© 2022 Meta ULC. All rights reserved